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Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review

Taylor, Kyla W. ; Novak, Raymond F. ; Anderson, Henry A. ; Birnbaum, Linda S. ; Blystone, Chad ; DeVito, Michael ; Jacobs, David ; Koehrle, Josef ; Lee, Duk-Hee and Rylander, Lars LU orcid , et al. (2013) In Environmental Health Perspectives 121(7). p.774-783
Abstract
BACKGROUND: Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. OBJECTIVE: We assessed the epidemiologic literature for evidence of associations between persistent organic pollutants (POPs) and type 2 diabetes. METHODS: Using a PubMed search and reference lists from relevant studies or review articles, we identified 72 epidemiological studies that investigated associations of persistent organic pollutants (POPs) with diabetes. We evaluated these studies for consistency, strengths and weaknesses of study design (including power and statistical methods), clinical diagnosis,... (More)
BACKGROUND: Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. OBJECTIVE: We assessed the epidemiologic literature for evidence of associations between persistent organic pollutants (POPs) and type 2 diabetes. METHODS: Using a PubMed search and reference lists from relevant studies or review articles, we identified 72 epidemiological studies that investigated associations of persistent organic pollutants (POPs) with diabetes. We evaluated these studies for consistency, strengths and weaknesses of study design (including power and statistical methods), clinical diagnosis, exposure assessment, study population characteristics, and identification of data gaps and areas for future research. CONCLUSIONS: Heterogeneity of the studies precluded conducting a meta-analysis, but the overall evidence is sufficient for a positive association of some organochlorine POPs with type 2 diabetes. Collectively, these data are not sufficient to establish causality. Initial data mining revealed that the strongest positive correlation of diabetes with POPs occurred with organochlorine compounds, such as trans-nonachlor, dichlorodiphenyldichloroethylene (DDE), polychlorinated biphenyls (PCBs), and dioxins and dioxin-like chemicals. There is less indication of an association between other nonorganochlorine POPs, such as perfluoroalkyl acids and brominated compounds, and type 2 diabetes. Experimental data are needed to confirm the causality of these POPs, which will shed new light on the pathogenesis of diabetes. This new information should be considered by governmental bodies involved in the regulation of environmental contaminants. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chemically induced, diabetes, environment, epidemiology, glucose, hormone, insulin, metabolic syndrome, obesity, persistent organic, pollutants, pollution, toxicology
in
Environmental Health Perspectives
volume
121
issue
7
pages
774 - 783
publisher
National Institute of Environmental Health Sciences
external identifiers
  • wos:000323711000015
  • scopus:84879557446
  • pmid:23651634
ISSN
1552-9924
DOI
10.1289/ehp.1205502
language
English
LU publication?
yes
id
c8c9cecf-d5fe-4920-879f-db795ca1c4a5 (old id 4062527)
date added to LUP
2016-04-01 13:56:02
date last changed
2022-03-14 02:49:17
@article{c8c9cecf-d5fe-4920-879f-db795ca1c4a5,
  abstract     = {{BACKGROUND: Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. OBJECTIVE: We assessed the epidemiologic literature for evidence of associations between persistent organic pollutants (POPs) and type 2 diabetes. METHODS: Using a PubMed search and reference lists from relevant studies or review articles, we identified 72 epidemiological studies that investigated associations of persistent organic pollutants (POPs) with diabetes. We evaluated these studies for consistency, strengths and weaknesses of study design (including power and statistical methods), clinical diagnosis, exposure assessment, study population characteristics, and identification of data gaps and areas for future research. CONCLUSIONS: Heterogeneity of the studies precluded conducting a meta-analysis, but the overall evidence is sufficient for a positive association of some organochlorine POPs with type 2 diabetes. Collectively, these data are not sufficient to establish causality. Initial data mining revealed that the strongest positive correlation of diabetes with POPs occurred with organochlorine compounds, such as trans-nonachlor, dichlorodiphenyldichloroethylene (DDE), polychlorinated biphenyls (PCBs), and dioxins and dioxin-like chemicals. There is less indication of an association between other nonorganochlorine POPs, such as perfluoroalkyl acids and brominated compounds, and type 2 diabetes. Experimental data are needed to confirm the causality of these POPs, which will shed new light on the pathogenesis of diabetes. This new information should be considered by governmental bodies involved in the regulation of environmental contaminants.}},
  author       = {{Taylor, Kyla W. and Novak, Raymond F. and Anderson, Henry A. and Birnbaum, Linda S. and Blystone, Chad and DeVito, Michael and Jacobs, David and Koehrle, Josef and Lee, Duk-Hee and Rylander, Lars and Rignell-Hydbom, Anna and Tornero-Velez, Rogelio and Turyk, Mary E. and Boyles, Abee L. and Thayer, Kristina A. and Lind, Lars}},
  issn         = {{1552-9924}},
  keywords     = {{chemically induced; diabetes; environment; epidemiology; glucose; hormone; insulin; metabolic syndrome; obesity; persistent organic; pollutants; pollution; toxicology}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{774--783}},
  publisher    = {{National Institute of Environmental Health Sciences}},
  series       = {{Environmental Health Perspectives}},
  title        = {{Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review}},
  url          = {{https://lup.lub.lu.se/search/files/3674164/4589278}},
  doi          = {{10.1289/ehp.1205502}},
  volume       = {{121}},
  year         = {{2013}},
}