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Intermittent scanning continuous glucose monitoring is safe and useful in postsurgical glucose monitoring after pancreatoduodenectomy

Fagher, Katarina LU ; Ekström, Eva LU ; Rystedt, Jenny LU ; Tingstedt, Bobby LU ; Andersson, Bodil LU orcid and Löndahl, Magnus LU (2023) In Acta Diabetologica 60(12). p.1727-1733
Abstract

Aims: Intermittently scanned continuous glucose monitoring (isCGM) systems have not been thoroughly evaluated during in-hospital stay, and there are concerns about accuracy during various conditions. Patients undergoing pancreatoduodenectomy have an increased risk of hyperglycaemia after surgery which is aggravated by parenteral nutrition therapy. This study aims to evaluate glycaemic control and safety during insulin infusion in a surgical non-ICU ward, using a hybrid glucose monitoring approach with isCMG and periodic point-of-care (POC) testing. Methods: We prospectively included 100 patients with a resectable pancreatic tumour. After surgery, continuous insulin infusion was initiated when POC glucose was > 7 mmol/l and titrated... (More)

Aims: Intermittently scanned continuous glucose monitoring (isCGM) systems have not been thoroughly evaluated during in-hospital stay, and there are concerns about accuracy during various conditions. Patients undergoing pancreatoduodenectomy have an increased risk of hyperglycaemia after surgery which is aggravated by parenteral nutrition therapy. This study aims to evaluate glycaemic control and safety during insulin infusion in a surgical non-ICU ward, using a hybrid glucose monitoring approach with isCMG and periodic point-of-care (POC) testing. Methods: We prospectively included 100 patients with a resectable pancreatic tumour. After surgery, continuous insulin infusion was initiated when POC glucose was > 7 mmol/l and titrated to maintain glucose between 7 and 10 mmol/l. Glucose was monitored with isCGM together with intermittent POC, every 3–6 h. Median absolute relative difference (MARD) and hypoglycaemic events were evaluated. Mean glucose was compared with a historic control (n = 100) treated with multiple subcutaneously insulin injections, monitored with POC only. Results: The intervention group (isCGM/POC) had significantly lower POC glucose compared with the historic control group (8.8 ± 2.2 vs. 10.4 ± 3.4 mmol/l, p < 0.001). MARD was 17.8% (IQR 10.2–26.7). isCGM readings were higher than POC measurements in 91% of the paired cases, and isCGM did not miss any hypoglycaemic event. About 4.5% of all isCGM readings were < 3.9 mmol/l, but only six events were confirmed with POC, and none was < 3.0 mmol/l. Conclusions: A hybrid approach with isCGM/POC is a safe and effective treatment option in a non-ICU setting after pancreatoduodenectomy.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CGM, Continuous glucose monitoring, Hospital, Surgery, Total parenteral nutrition
in
Acta Diabetologica
volume
60
issue
12
pages
7 pages
publisher
Springer
external identifiers
  • pmid:37540239
  • scopus:85166631050
ISSN
0940-5429
DOI
10.1007/s00592-023-02158-0
language
English
LU publication?
yes
id
c8ee9070-4cf1-4f26-a423-f05f436a2ff1
date added to LUP
2023-11-21 13:02:39
date last changed
2024-04-18 16:14:49
@article{c8ee9070-4cf1-4f26-a423-f05f436a2ff1,
  abstract     = {{<p>Aims: Intermittently scanned continuous glucose monitoring (isCGM) systems have not been thoroughly evaluated during in-hospital stay, and there are concerns about accuracy during various conditions. Patients undergoing pancreatoduodenectomy have an increased risk of hyperglycaemia after surgery which is aggravated by parenteral nutrition therapy. This study aims to evaluate glycaemic control and safety during insulin infusion in a surgical non-ICU ward, using a hybrid glucose monitoring approach with isCMG and periodic point-of-care (POC) testing. Methods: We prospectively included 100 patients with a resectable pancreatic tumour. After surgery, continuous insulin infusion was initiated when POC glucose was &gt; 7 mmol/l and titrated to maintain glucose between 7 and 10 mmol/l. Glucose was monitored with isCGM together with intermittent POC, every 3–6 h. Median absolute relative difference (MARD) and hypoglycaemic events were evaluated. Mean glucose was compared with a historic control (n = 100) treated with multiple subcutaneously insulin injections, monitored with POC only. Results: The intervention group (isCGM/POC) had significantly lower POC glucose compared with the historic control group (8.8 ± 2.2 vs. 10.4 ± 3.4 mmol/l, p &lt; 0.001). MARD was 17.8% (IQR 10.2–26.7). isCGM readings were higher than POC measurements in 91% of the paired cases, and isCGM did not miss any hypoglycaemic event. About 4.5% of all isCGM readings were &lt; 3.9 mmol/l, but only six events were confirmed with POC, and none was &lt; 3.0 mmol/l. Conclusions: A hybrid approach with isCGM/POC is a safe and effective treatment option in a non-ICU setting after pancreatoduodenectomy.</p>}},
  author       = {{Fagher, Katarina and Ekström, Eva and Rystedt, Jenny and Tingstedt, Bobby and Andersson, Bodil and Löndahl, Magnus}},
  issn         = {{0940-5429}},
  keywords     = {{CGM; Continuous glucose monitoring; Hospital; Surgery; Total parenteral nutrition}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1727--1733}},
  publisher    = {{Springer}},
  series       = {{Acta Diabetologica}},
  title        = {{Intermittent scanning continuous glucose monitoring is safe and useful in postsurgical glucose monitoring after pancreatoduodenectomy}},
  url          = {{http://dx.doi.org/10.1007/s00592-023-02158-0}},
  doi          = {{10.1007/s00592-023-02158-0}},
  volume       = {{60}},
  year         = {{2023}},
}