Exosomes in Parkinson's Disease : Current Perspectives and Future Challenges
(2019) In ACS Chemical Neuroscience 10(2). p.964-972- Abstract
Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be... (More)
Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be loaded with defined therapeutically active molecules, such as drugs, small interfering RNAs, long noncoding RNAs, and proteins to the brain, ensuring the site-specific targeting strategy to the recipient cells. Therefore, we will also discuss the potential applications of exosomes in developing modified exosome-based drug carrier systems to halt the pathologic propagation of Parkinson's disease.
(Less)
- author
- Yuan, Lin and Li, Jia Yi LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Exosomes, Parkinson's disease, α-synuclein
- in
- ACS Chemical Neuroscience
- volume
- 10
- issue
- 2
- pages
- 964 - 972
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85061267080
- pmid:30664350
- ISSN
- 1948-7193
- DOI
- 10.1021/acschemneuro.8b00469
- language
- English
- LU publication?
- yes
- id
- c959b276-11d1-472a-95dc-c93af269a601
- date added to LUP
- 2019-02-21 14:21:09
- date last changed
- 2024-06-11 05:26:11
@article{c959b276-11d1-472a-95dc-c93af269a601,
abstract = {{<p>Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be loaded with defined therapeutically active molecules, such as drugs, small interfering RNAs, long noncoding RNAs, and proteins to the brain, ensuring the site-specific targeting strategy to the recipient cells. Therefore, we will also discuss the potential applications of exosomes in developing modified exosome-based drug carrier systems to halt the pathologic propagation of Parkinson's disease.</p>}},
author = {{Yuan, Lin and Li, Jia Yi}},
issn = {{1948-7193}},
keywords = {{Exosomes; Parkinson's disease; α-synuclein}},
language = {{eng}},
number = {{2}},
pages = {{964--972}},
publisher = {{The American Chemical Society (ACS)}},
series = {{ACS Chemical Neuroscience}},
title = {{Exosomes in Parkinson's Disease : Current Perspectives and Future Challenges}},
url = {{http://dx.doi.org/10.1021/acschemneuro.8b00469}},
doi = {{10.1021/acschemneuro.8b00469}},
volume = {{10}},
year = {{2019}},
}