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Exosomes in Parkinson's Disease : Current Perspectives and Future Challenges

Yuan, Lin and Li, Jia Yi LU (2019) In ACS Chemical Neuroscience 10(2). p.964-972
Abstract

Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be... (More)

Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be loaded with defined therapeutically active molecules, such as drugs, small interfering RNAs, long noncoding RNAs, and proteins to the brain, ensuring the site-specific targeting strategy to the recipient cells. Therefore, we will also discuss the potential applications of exosomes in developing modified exosome-based drug carrier systems to halt the pathologic propagation of Parkinson's disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Exosomes, Parkinson's disease, α-synuclein
in
ACS Chemical Neuroscience
volume
10
issue
2
pages
964 - 972
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85061267080
ISSN
1948-7193
DOI
10.1021/acschemneuro.8b00469
language
English
LU publication?
yes
id
c959b276-11d1-472a-95dc-c93af269a601
date added to LUP
2019-02-21 14:21:09
date last changed
2019-10-15 06:59:03
@article{c959b276-11d1-472a-95dc-c93af269a601,
  abstract     = {<p>Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be loaded with defined therapeutically active molecules, such as drugs, small interfering RNAs, long noncoding RNAs, and proteins to the brain, ensuring the site-specific targeting strategy to the recipient cells. Therefore, we will also discuss the potential applications of exosomes in developing modified exosome-based drug carrier systems to halt the pathologic propagation of Parkinson's disease.</p>},
  author       = {Yuan, Lin and Li, Jia Yi},
  issn         = {1948-7193},
  keyword      = {Exosomes,Parkinson's disease,α-synuclein},
  language     = {eng},
  number       = {2},
  pages        = {964--972},
  publisher    = {The American Chemical Society (ACS)},
  series       = {ACS Chemical Neuroscience},
  title        = {Exosomes in Parkinson's Disease : Current Perspectives and Future Challenges},
  url          = {http://dx.doi.org/10.1021/acschemneuro.8b00469},
  volume       = {10},
  year         = {2019},
}