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Geographical differences in tonsillar carriage rates of Fusobacterium necrophorum – A cross-sectional study in Sweden and Zambia

Nygren, David LU orcid ; Brorson, Ellen LU ; Musonda, Michael ; Wasserstrom, Lisa ; Johansson, Åsa and Holm, Karin LU (2021) In Anaerobe 69.
Abstract

While Fusobacterium necrophorum historically has been considered normal tonsillar flora, recent studies from Europe and the US have suggested that carriage occur transiently in adolescence and young adulthood. However, no studies originating from Africa exist. In this cross-sectional study of tonsillar carriage of F. necrophorum, we aimed to investigate geographical differences in tonsillar carriage rates of F. necrophorum in healthy participants aged 15–25 years in Sweden and Zambia and further investigate the age distribution of tonsillar carriage in Zambia. Specimens were obtained by tonsillar swabs and analyzed with real-time PCR for F. necrophorum. In participants aged 15–25 years, tonsillar carriage was more common in Sweden... (More)

While Fusobacterium necrophorum historically has been considered normal tonsillar flora, recent studies from Europe and the US have suggested that carriage occur transiently in adolescence and young adulthood. However, no studies originating from Africa exist. In this cross-sectional study of tonsillar carriage of F. necrophorum, we aimed to investigate geographical differences in tonsillar carriage rates of F. necrophorum in healthy participants aged 15–25 years in Sweden and Zambia and further investigate the age distribution of tonsillar carriage in Zambia. Specimens were obtained by tonsillar swabs and analyzed with real-time PCR for F. necrophorum. In participants aged 15–25 years, tonsillar carriage was more common in Sweden 21/100 (21%) than in Zambia 6/192 (3%), p < 0.001. In Zambian participants aged above 25 years tonsillar carriage was rare 1/76 (1%). In conclusion, the high rate of tonsillar carriage in participants aged 15–25 years in Sweden has implications on the interpretation of tonsillar findings in patients with pharyngotonsillitis. Interestingly, a geographical difference was found with tonsillar carriage rarely identified in Zambia.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fusobacterium necrophorum, Geographical difference, Sweden, Tonsillar carriage, Tonsillar flora, Zambia
in
Anaerobe
volume
69
article number
102360
publisher
Elsevier
external identifiers
  • pmid:33757851
  • scopus:85103397696
ISSN
1075-9964
DOI
10.1016/j.anaerobe.2021.102360
language
English
LU publication?
yes
id
c9690512-8cf3-46a3-89d4-51b4cfbea841
date added to LUP
2021-04-12 09:13:21
date last changed
2024-04-20 05:36:54
@article{c9690512-8cf3-46a3-89d4-51b4cfbea841,
  abstract     = {{<p>While Fusobacterium necrophorum historically has been considered normal tonsillar flora, recent studies from Europe and the US have suggested that carriage occur transiently in adolescence and young adulthood. However, no studies originating from Africa exist. In this cross-sectional study of tonsillar carriage of F. necrophorum, we aimed to investigate geographical differences in tonsillar carriage rates of F. necrophorum in healthy participants aged 15–25 years in Sweden and Zambia and further investigate the age distribution of tonsillar carriage in Zambia. Specimens were obtained by tonsillar swabs and analyzed with real-time PCR for F. necrophorum. In participants aged 15–25 years, tonsillar carriage was more common in Sweden 21/100 (21%) than in Zambia 6/192 (3%), p &lt; 0.001. In Zambian participants aged above 25 years tonsillar carriage was rare 1/76 (1%). In conclusion, the high rate of tonsillar carriage in participants aged 15–25 years in Sweden has implications on the interpretation of tonsillar findings in patients with pharyngotonsillitis. Interestingly, a geographical difference was found with tonsillar carriage rarely identified in Zambia.</p>}},
  author       = {{Nygren, David and Brorson, Ellen and Musonda, Michael and Wasserstrom, Lisa and Johansson, Åsa and Holm, Karin}},
  issn         = {{1075-9964}},
  keywords     = {{Fusobacterium necrophorum; Geographical difference; Sweden; Tonsillar carriage; Tonsillar flora; Zambia}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Anaerobe}},
  title        = {{Geographical differences in tonsillar carriage rates of Fusobacterium necrophorum – A cross-sectional study in Sweden and Zambia}},
  url          = {{http://dx.doi.org/10.1016/j.anaerobe.2021.102360}},
  doi          = {{10.1016/j.anaerobe.2021.102360}},
  volume       = {{69}},
  year         = {{2021}},
}