Excitatory amino acids and cerebrovascular tone
(1989) In Acta Physiologica Scandinavica 136(3). p.483-485- Abstract
Levels of excitatory amino acids in the brain extracellular fluid compartment rise during pathological conditions in the brain such as ischaemia, anoxia and epilepsy. One such amino acid, glutamate, is present in sensory nerve fibres innervating, for example, cerebral vessels. Enhanced levels of circulating glutamate and aspartate are found in migraine sufferers. The present study examined whether excitatory amino acids, in concentrations found in the brain extracellular fluid compartment during pathological conditions, exert a direct effect on cerebrovascular tone. As tested in flow-regulating pial arteries from rat, cat and man, no such constrictive or dilatory effect was obtained.
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https://lup.lub.lu.se/record/c99e05ba-ebab-4ec0-bfa7-3b31e57a2568
- author
- Hardebo, J. E. LU ; Wieloch, T. LU and Kahrstrom, J.
- organization
- publishing date
- 1989-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Acta Physiologica Scandinavica
- volume
- 136
- issue
- 3
- pages
- 3 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:2546374
- scopus:0024360735
- ISSN
- 0001-6772
- language
- English
- LU publication?
- yes
- id
- c99e05ba-ebab-4ec0-bfa7-3b31e57a2568
- date added to LUP
- 2019-06-13 17:33:24
- date last changed
- 2024-01-01 10:28:57
@article{c99e05ba-ebab-4ec0-bfa7-3b31e57a2568,
abstract = {{<p>Levels of excitatory amino acids in the brain extracellular fluid compartment rise during pathological conditions in the brain such as ischaemia, anoxia and epilepsy. One such amino acid, glutamate, is present in sensory nerve fibres innervating, for example, cerebral vessels. Enhanced levels of circulating glutamate and aspartate are found in migraine sufferers. The present study examined whether excitatory amino acids, in concentrations found in the brain extracellular fluid compartment during pathological conditions, exert a direct effect on cerebrovascular tone. As tested in flow-regulating pial arteries from rat, cat and man, no such constrictive or dilatory effect was obtained.</p>}},
author = {{Hardebo, J. E. and Wieloch, T. and Kahrstrom, J.}},
issn = {{0001-6772}},
language = {{eng}},
month = {{01}},
number = {{3}},
pages = {{483--485}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Physiologica Scandinavica}},
title = {{Excitatory amino acids and cerebrovascular tone}},
volume = {{136}},
year = {{1989}},
}