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Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides

Ekström, Per A R LU and Tomlinson, David R. (1990) In Experimental Neurology 109(2). p.200-203
Abstract

The rate of sciatic nerve regeneration and the effect of ganglioside treatment thereon were studied in the streptozotocin-diabetic rat. Two experimental protocols were used. In the first, sciatic nerves were crushed at 3 weeks of diabetes and treatment with purified bovine brain gangliosides (10 mg/kg/day ip) was begun the day before crush. In the second, nerves were crushed at 5 weeks of diabetes and treatment was started 7 days before crush. Regeneration was evaluated in both cases with the pinch-reflex test at different time points after crush. In either situation untreated diabetic rats showed a decreased rate of regeneration when compared to untreated nondiabetic rats, with a more severe reduction in 5-week diabetic rats.... (More)

The rate of sciatic nerve regeneration and the effect of ganglioside treatment thereon were studied in the streptozotocin-diabetic rat. Two experimental protocols were used. In the first, sciatic nerves were crushed at 3 weeks of diabetes and treatment with purified bovine brain gangliosides (10 mg/kg/day ip) was begun the day before crush. In the second, nerves were crushed at 5 weeks of diabetes and treatment was started 7 days before crush. Regeneration was evaluated in both cases with the pinch-reflex test at different time points after crush. In either situation untreated diabetic rats showed a decreased rate of regeneration when compared to untreated nondiabetic rats, with a more severe reduction in 5-week diabetic rats. Ganglioside treatment improved regeneration in the second protocol; untreated diabetic rats had regenerated 10.6 ±0.9 mm (mean ± SEM) at 7 days postcrush, while nerves from ganglioside-treated and control rats had regenerated 16.4 ± 1.1 and 20.3 ± 1.0 mm, respectively (n = 9-11, P < 0.001 for untreated vs ganglioside-treated diabetics with two-way ANOVA). Ganglioside treatment did not alter the rate of regeneration in nondiabetic rats. © 1990.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Neurology
volume
109
issue
2
pages
200 - 203
publisher
Academic Press
external identifiers
  • scopus:0025180063
ISSN
0014-4886
DOI
10.1016/0014-4886(90)90074-3
language
English
LU publication?
no
id
c9b0de33-02ff-4677-9f89-1aea3e9b4d2e
date added to LUP
2016-12-07 14:33:55
date last changed
2017-07-09 04:55:56
@article{c9b0de33-02ff-4677-9f89-1aea3e9b4d2e,
  abstract     = {<p>The rate of sciatic nerve regeneration and the effect of ganglioside treatment thereon were studied in the streptozotocin-diabetic rat. Two experimental protocols were used. In the first, sciatic nerves were crushed at 3 weeks of diabetes and treatment with purified bovine brain gangliosides (10 mg/kg/day ip) was begun the day before crush. In the second, nerves were crushed at 5 weeks of diabetes and treatment was started 7 days before crush. Regeneration was evaluated in both cases with the pinch-reflex test at different time points after crush. In either situation untreated diabetic rats showed a decreased rate of regeneration when compared to untreated nondiabetic rats, with a more severe reduction in 5-week diabetic rats. Ganglioside treatment improved regeneration in the second protocol; untreated diabetic rats had regenerated 10.6 ±0.9 mm (mean ± SEM) at 7 days postcrush, while nerves from ganglioside-treated and control rats had regenerated 16.4 ± 1.1 and 20.3 ± 1.0 mm, respectively (n = 9-11, P &lt; 0.001 for untreated vs ganglioside-treated diabetics with two-way ANOVA). Ganglioside treatment did not alter the rate of regeneration in nondiabetic rats. © 1990.</p>},
  author       = {Ekström, Per A R and Tomlinson, David R.},
  issn         = {0014-4886},
  language     = {eng},
  number       = {2},
  pages        = {200--203},
  publisher    = {Academic Press},
  series       = {Experimental Neurology},
  title        = {Impaired nerve regeneration in streptozotocin-diabetic rats is improved by treatment with gangliosides},
  url          = {http://dx.doi.org/10.1016/0014-4886(90)90074-3},
  volume       = {109},
  year         = {1990},
}