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Selenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure

Ohlsson, Marcus Andréas LU orcid ; Molvin, John LU ; Holm Isholth, Hannes LU ; Christensson, Anders LU ; Nilsson, Christopher LU orcid ; Laucyte-Cibulskiene, Agne LU orcid ; Grubb, Anders LU orcid ; Schomburg, Lutz ; Jujic, Amra LU orcid and Magnusson, Martin LU orcid (2026) In Nutrients 18(5). p.1-12
Abstract
Selenium (Se), an essential trace element, is linked to poor prognosis in heart failure (HF) and kidney disease. Se deficiency (serum Se < 70 μg/L) has been associated with increased cardiovascular mortality. Selenoprotein P (SELENOP), the main Se transporter, reflects bioavailable Se. Selective glomerular hypofiltration syndrome (SGHS), defined by a cystatin C-based eGFR < 0.7 of creatinine-based eGFR, signals early kidney dysfunction and worsens HF outcomes. The prognostic role of SELENOP for SGHS and kidney-related hospitalization in HF remains unclear. Purpose: To assess whether SELENOP is associated with SGHS at baseline and future kidney disease hospitalization in acute HF patients. Methods: In 570 patients hospitalized for... (More)
Selenium (Se), an essential trace element, is linked to poor prognosis in heart failure (HF) and kidney disease. Se deficiency (serum Se < 70 μg/L) has been associated with increased cardiovascular mortality. Selenoprotein P (SELENOP), the main Se transporter, reflects bioavailable Se. Selective glomerular hypofiltration syndrome (SGHS), defined by a cystatin C-based eGFR < 0.7 of creatinine-based eGFR, signals early kidney dysfunction and worsens HF outcomes. The prognostic role of SELENOP for SGHS and kidney-related hospitalization in HF remains unclear. Purpose: To assess whether SELENOP is associated with SGHS at baseline and future kidney disease hospitalization in acute HF patients. Methods: In 570 patients hospitalized for acute HF, creatinine and cystatin C were analyzed; SELENOP was measured in the first 320 using an immunoassay. Kidney hospitalizations (ICD-10 N17–N19) were identified from regional registries. Logistic and Cox regression models evaluated SELENOP’s association with SGHS and hospitalization risk, adjusting for age, sex, blood pressure, BMI, eGFR and NT-proBNP. Results: Among 320 patients (mean age 75 years, 69% male), 58% had Se deficiency, and 30% had SGHS. During a median 43-month follow-up, 28 patients were hospitalized for kidney disease. Higher SELENOP was linked to lower odds of SGHS (OR 0.69; p = 0.002) and reduced risk of hospitalization for AKI or CKD (HR 0.60; p = 0.010), particularly AKI (HR 0.42; p = 0.002). SELENOP-deficiency (<3.23 mg/L) predicted AKI hospitalization (HR 4.02; p = 0.035). Conclusions: Low SELENOP is associated with SGHS and increased risk of kidney disease hospitalization, especially AKI, suggesting Se status may influence HF and renal outcomes. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrients
volume
18
issue
5
pages
1 - 12
publisher
MDPI AG
ISSN
2072-6643
DOI
10.3390/nu18050721
language
English
LU publication?
yes
id
c9e8086e-1583-4182-a048-5457a77c07ff
date added to LUP
2026-02-24 15:37:04
date last changed
2026-02-25 07:11:58
@article{c9e8086e-1583-4182-a048-5457a77c07ff,
  abstract     = {{Selenium (Se), an essential trace element, is linked to poor prognosis in heart failure (HF) and kidney disease. Se deficiency (serum Se &lt; 70 μg/L) has been associated with increased cardiovascular mortality. Selenoprotein P (SELENOP), the main Se transporter, reflects bioavailable Se. Selective glomerular hypofiltration syndrome (SGHS), defined by a cystatin C-based eGFR &lt; 0.7 of creatinine-based eGFR, signals early kidney dysfunction and worsens HF outcomes. The prognostic role of SELENOP for SGHS and kidney-related hospitalization in HF remains unclear. Purpose: To assess whether SELENOP is associated with SGHS at baseline and future kidney disease hospitalization in acute HF patients. Methods: In 570 patients hospitalized for acute HF, creatinine and cystatin C were analyzed; SELENOP was measured in the first 320 using an immunoassay. Kidney hospitalizations (ICD-10 N17–N19) were identified from regional registries. Logistic and Cox regression models evaluated SELENOP’s association with SGHS and hospitalization risk, adjusting for age, sex, blood pressure, BMI, eGFR and NT-proBNP. Results: Among 320 patients (mean age 75 years, 69% male), 58% had Se deficiency, and 30% had SGHS. During a median 43-month follow-up, 28 patients were hospitalized for kidney disease. Higher SELENOP was linked to lower odds of SGHS (OR 0.69; p = 0.002) and reduced risk of hospitalization for AKI or CKD (HR 0.60; p = 0.010), particularly AKI (HR 0.42; p = 0.002). SELENOP-deficiency (&lt;3.23 mg/L) predicted AKI hospitalization (HR 4.02; p = 0.035). Conclusions: Low SELENOP is associated with SGHS and increased risk of kidney disease hospitalization, especially AKI, suggesting Se status may influence HF and renal outcomes.}},
  author       = {{Ohlsson, Marcus Andréas and Molvin, John and Holm Isholth, Hannes and Christensson, Anders and Nilsson, Christopher and Laucyte-Cibulskiene, Agne and Grubb, Anders and Schomburg, Lutz and Jujic, Amra and Magnusson, Martin}},
  issn         = {{2072-6643}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{5}},
  pages        = {{1--12}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Selenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure}},
  url          = {{http://dx.doi.org/10.3390/nu18050721}},
  doi          = {{10.3390/nu18050721}},
  volume       = {{18}},
  year         = {{2026}},
}