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Pitfalls using metalloporphyrins in carbon monoxide research

Grundemar, L LU and Ny, L (1997) In Trends in Pharmacological Sciences 18(6). p.193-195
Abstract

The proposal that endogenously produced carbon monoxide (CO) may act as a biological messenger has remained controversial. Carbon monoxide is generated by haem oxygenase isoenzymes in the degradation of haem-containing molecules. Certain metalloporphyrins, which are inhibitors of haem oxygenase, have been widely used as pharmacological tools in order to establish a messenger role for CO in the brain and periphery. However, increasing evidence shows that many metalloporphyrins are also associated with a large range of undesired effects, which make the interpretation of results using such compounds very uncertain. In this article, Lars Grundemar and Lars Ny evaluate the properties and describe the nonselective effect profile of such... (More)

The proposal that endogenously produced carbon monoxide (CO) may act as a biological messenger has remained controversial. Carbon monoxide is generated by haem oxygenase isoenzymes in the degradation of haem-containing molecules. Certain metalloporphyrins, which are inhibitors of haem oxygenase, have been widely used as pharmacological tools in order to establish a messenger role for CO in the brain and periphery. However, increasing evidence shows that many metalloporphyrins are also associated with a large range of undesired effects, which make the interpretation of results using such compounds very uncertain. In this article, Lars Grundemar and Lars Ny evaluate the properties and describe the nonselective effect profile of such metalloporphyrins.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Brain/drug effects, Carbon Monoxide/metabolism, Enzyme Inhibitors/metabolism, Heme Oxygenase (Decyclizing)/antagonists & inhibitors, Metalloporphyrins/metabolism, Protoporphyrins/metabolism, RNA, Messenger/metabolism
in
Trends in Pharmacological Sciences
volume
18
issue
6
pages
193 - 195
publisher
Elsevier
external identifiers
  • scopus:0030834118
ISSN
0165-6147
DOI
10.1016/S0165-6147(97)01065-1
language
English
LU publication?
no
id
ca06ea84-c1fa-4aa2-9a01-ad6544bb4b93
date added to LUP
2019-09-03 13:58:53
date last changed
2019-09-17 05:00:01
@article{ca06ea84-c1fa-4aa2-9a01-ad6544bb4b93,
  abstract     = {<p>The proposal that endogenously produced carbon monoxide (CO) may act as a biological messenger has remained controversial. Carbon monoxide is generated by haem oxygenase isoenzymes in the degradation of haem-containing molecules. Certain metalloporphyrins, which are inhibitors of haem oxygenase, have been widely used as pharmacological tools in order to establish a messenger role for CO in the brain and periphery. However, increasing evidence shows that many metalloporphyrins are also associated with a large range of undesired effects, which make the interpretation of results using such compounds very uncertain. In this article, Lars Grundemar and Lars Ny evaluate the properties and describe the nonselective effect profile of such metalloporphyrins.</p>},
  author       = {Grundemar, L and Ny, L},
  issn         = {0165-6147},
  keyword      = {Animals,Brain/drug effects,Carbon Monoxide/metabolism,Enzyme Inhibitors/metabolism,Heme Oxygenase (Decyclizing)/antagonists & inhibitors,Metalloporphyrins/metabolism,Protoporphyrins/metabolism,RNA, Messenger/metabolism},
  language     = {eng},
  number       = {6},
  pages        = {193--195},
  publisher    = {Elsevier},
  series       = {Trends in Pharmacological Sciences},
  title        = {Pitfalls using metalloporphyrins in carbon monoxide research},
  url          = {http://dx.doi.org/10.1016/S0165-6147(97)01065-1},
  volume       = {18},
  year         = {1997},
}