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Platelet transfusions and thrombocytopenia in intensive care units : Protocol for an international inception cohort study (PLOT-ICU)

Anthon, Carl Thomas ; Pène, Frédéric ; Perner, Anders ; Azoulay, Elie ; Puxty, Kathryn ; Van De Louw, Andry ; Barratt-Due, Andreas ; Chawla, Sanjay ; Castro, Pedro and Povoa, Pedro , et al. (2022) In Acta Anaesthesiologica Scandinavica 66(9). p.1146-1155
Abstract

Introduction: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU. Methods: We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90 days. The primary outcome will... (More)

Introduction: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU. Methods: We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90 days. The primary outcome will be the number of patients with thrombocytopenia (a recorded platelet count < 150 × 109/L) at baseline and/or during ICU stay. Secondary outcomes include mortality, days alive and out of hospital, days alive without life-support, the number of patients with at least one bleeding episode, at least one thromboembolic event and at least one platelet transfusion in the ICU, the number of platelet transfusions and the indications for transfusion. The primary and secondary outcomes will be presented descriptively. In addition, we will assess risk factors for developing thrombocytopenia during ICU stay and the association between thrombocytopenia at baseline and 90-day mortality using logistic regression analyses. Conclusion: The outlined international PLOT-ICU cohort study will provide contemporary epidemiological data on the burden and clinical significance of thrombocytopenia in adult ICU patients and describe the current platelet transfusion practice.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intensive care unit, platelet transfusion, thrombocytopenia
in
Acta Anaesthesiologica Scandinavica
volume
66
issue
9
pages
1146 - 1155
publisher
Wiley-Blackwell
external identifiers
  • pmid:36054145
  • scopus:85136980553
ISSN
0001-5172
DOI
10.1111/aas.14124
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
id
ca1bfe81-edb9-4271-a1f5-48322906e4f7
date added to LUP
2022-09-08 22:07:45
date last changed
2024-04-29 21:00:24
@article{ca1bfe81-edb9-4271-a1f5-48322906e4f7,
  abstract     = {{<p>Introduction: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU. Methods: We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90 days. The primary outcome will be the number of patients with thrombocytopenia (a recorded platelet count &lt; 150 × 10<sup>9</sup>/L) at baseline and/or during ICU stay. Secondary outcomes include mortality, days alive and out of hospital, days alive without life-support, the number of patients with at least one bleeding episode, at least one thromboembolic event and at least one platelet transfusion in the ICU, the number of platelet transfusions and the indications for transfusion. The primary and secondary outcomes will be presented descriptively. In addition, we will assess risk factors for developing thrombocytopenia during ICU stay and the association between thrombocytopenia at baseline and 90-day mortality using logistic regression analyses. Conclusion: The outlined international PLOT-ICU cohort study will provide contemporary epidemiological data on the burden and clinical significance of thrombocytopenia in adult ICU patients and describe the current platelet transfusion practice.</p>}},
  author       = {{Anthon, Carl Thomas and Pène, Frédéric and Perner, Anders and Azoulay, Elie and Puxty, Kathryn and Van De Louw, Andry and Barratt-Due, Andreas and Chawla, Sanjay and Castro, Pedro and Povoa, Pedro and Coelho, Luis and Metaxa, Victoria and Munshi, Laveena and Kochanek, Matthias and Liebregts, Tobias and Kander, Thomas and Hästbacka, Johanna and Møller, Morten Hylander and Russell, Lene}},
  issn         = {{0001-5172}},
  keywords     = {{intensive care unit; platelet transfusion; thrombocytopenia}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1146--1155}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Anaesthesiologica Scandinavica}},
  title        = {{Platelet transfusions and thrombocytopenia in intensive care units : Protocol for an international inception cohort study (PLOT-ICU)}},
  url          = {{http://dx.doi.org/10.1111/aas.14124}},
  doi          = {{10.1111/aas.14124}},
  volume       = {{66}},
  year         = {{2022}},
}