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Role of the axonal initial segment in psychiatric disorders : function, dysfunction, and intervention

Hsu, Wei-Chun Jim; Nilsson, Carol Lynn LU and Laezza, Fernanda (2014) In Frontiers in Psychiatry 5.
Abstract

The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initial segment (AIS), a highly specialized neuronal structure critical for spike initiation of the action potential. In particular, the role of voltage-gated sodium channels, and their interactions with other protein partners in a tightly regulated macromolecular complex has been emphasized as a key component in the regulation of neuronal excitability. Deficits and excesses of excitability have been linked to the pathogenesis of... (More)

The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initial segment (AIS), a highly specialized neuronal structure critical for spike initiation of the action potential. In particular, the role of voltage-gated sodium channels, and their interactions with other protein partners in a tightly regulated macromolecular complex has been emphasized as a key component in the regulation of neuronal excitability. Deficits and excesses of excitability have been linked to the pathogenesis of brain disorders. Identification of the factors and regulatory pathways involved in proper AIS function, or its disruption, can lead to the development of novel interventions that target these mechanistic interactions, increasing treatment efficacy while reducing deleterious off-target effects for psychiatric disorders.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article, Review
in
Frontiers in Psychiatry
volume
5
publisher
Frontiers Media S. A.
external identifiers
  • scopus:84922327795
ISSN
1664-0640
DOI
10.3389/fpsyt.2014.00109
language
English
LU publication?
no
id
ca5129dc-be23-4463-8d4a-0d2f72a2f150
date added to LUP
2017-05-16 10:26:54
date last changed
2017-07-30 05:25:10
@article{ca5129dc-be23-4463-8d4a-0d2f72a2f150,
  abstract     = {<p>The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initial segment (AIS), a highly specialized neuronal structure critical for spike initiation of the action potential. In particular, the role of voltage-gated sodium channels, and their interactions with other protein partners in a tightly regulated macromolecular complex has been emphasized as a key component in the regulation of neuronal excitability. Deficits and excesses of excitability have been linked to the pathogenesis of brain disorders. Identification of the factors and regulatory pathways involved in proper AIS function, or its disruption, can lead to the development of novel interventions that target these mechanistic interactions, increasing treatment efficacy while reducing deleterious off-target effects for psychiatric disorders.</p>},
  articleno    = {109},
  author       = {Hsu, Wei-Chun Jim and Nilsson, Carol Lynn and Laezza, Fernanda},
  issn         = {1664-0640},
  keyword      = {Journal Article,Review},
  language     = {eng},
  publisher    = {Frontiers Media S. A.},
  series       = {Frontiers in Psychiatry},
  title        = {Role of the axonal initial segment in psychiatric disorders : function, dysfunction, and intervention},
  url          = {http://dx.doi.org/10.3389/fpsyt.2014.00109},
  volume       = {5},
  year         = {2014},
}