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Evaluation of nitrogen dioxide scavengers during delivery of inhaled nitric oxide

Lindberg, L LU and Rydgren, G (1998) In British Journal of Anaesthesia 81(3). p.404-408
Abstract

We have analysed the ability of three nitrogen dioxide absorbing materials (soda lime, noXon and zeolite) to act as nitrogen dioxide scavengers during delivery of inhaled nitric oxide. Different mixtures of gas were produced in a ventilator (Servo Ventilator 300) and passed through an inspiratory tube. Concentrations of nitrogen dioxide and nitric oxide were measured in the distal part of the tube, with and without the gas having passed through a canister containing the different filter materials. Our findings indicated that nitrogen dioxide was absorbed effectively by all filter materials but that there was re-formation of nitrogen dioxide from nitric oxide and oxygen in or immediately after the canister. This initial production of... (More)

We have analysed the ability of three nitrogen dioxide absorbing materials (soda lime, noXon and zeolite) to act as nitrogen dioxide scavengers during delivery of inhaled nitric oxide. Different mixtures of gas were produced in a ventilator (Servo Ventilator 300) and passed through an inspiratory tube. Concentrations of nitrogen dioxide and nitric oxide were measured in the distal part of the tube, with and without the gas having passed through a canister containing the different filter materials. Our findings indicated that nitrogen dioxide was absorbed effectively by all filter materials but that there was re-formation of nitrogen dioxide from nitric oxide and oxygen in or immediately after the canister. This initial production of nitrogen dioxide was very rapid and could not be prevented by the use of scavengers. Thus soda lime and zeolite had no practical effect as scavengers in this delivery system, and the effect of noXon was very slight.

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author
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Contribution to journal
publication status
published
subject
keywords
Absorption, Administration, Inhalation, Calcium Compounds, Evaluation Studies as Topic, Gas Scavengers, Humans, Nitric Oxide, Nitrogen Dioxide, Oxidation-Reduction, Oxides, Sodium Hydroxide, Zeolites, Journal Article
in
British Journal of Anaesthesia
volume
81
issue
3
pages
5 pages
publisher
Macmillan
external identifiers
  • scopus:0031718303
ISSN
0007-0912
DOI
10.1093/bja/81.3.404 hide
language
English
LU publication?
no
id
ca707e57-3b99-4a97-8d81-8ab8edcaab7c
date added to LUP
2018-04-25 14:00:57
date last changed
2018-11-21 21:39:33
@article{ca707e57-3b99-4a97-8d81-8ab8edcaab7c,
  abstract     = {<p>We have analysed the ability of three nitrogen dioxide absorbing materials (soda lime, noXon and zeolite) to act as nitrogen dioxide scavengers during delivery of inhaled nitric oxide. Different mixtures of gas were produced in a ventilator (Servo Ventilator 300) and passed through an inspiratory tube. Concentrations of nitrogen dioxide and nitric oxide were measured in the distal part of the tube, with and without the gas having passed through a canister containing the different filter materials. Our findings indicated that nitrogen dioxide was absorbed effectively by all filter materials but that there was re-formation of nitrogen dioxide from nitric oxide and oxygen in or immediately after the canister. This initial production of nitrogen dioxide was very rapid and could not be prevented by the use of scavengers. Thus soda lime and zeolite had no practical effect as scavengers in this delivery system, and the effect of noXon was very slight.</p>},
  author       = {Lindberg, L and Rydgren, G},
  issn         = {0007-0912},
  keyword      = {Absorption,Administration, Inhalation,Calcium Compounds,Evaluation Studies as Topic,Gas Scavengers,Humans,Nitric Oxide,Nitrogen Dioxide,Oxidation-Reduction,Oxides,Sodium Hydroxide,Zeolites,Journal Article},
  language     = {eng},
  number       = {3},
  pages        = {404--408},
  publisher    = {Macmillan},
  series       = {British Journal of Anaesthesia},
  title        = {Evaluation of nitrogen dioxide scavengers during delivery of inhaled nitric oxide},
  url          = {http://dx.doi.org/10.1093/bja/81.3.404 hide},
  volume       = {81},
  year         = {1998},
}