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RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3

Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M. LU ; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L. and La Cava, S., et al. (2016) In Food and Chemical Toxicology 97. p.192-200
Abstract

Summary: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental... (More)

Summary: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2).

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publication status
published
subject
keywords
Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
in
Food and Chemical Toxicology
volume
97
pages
192 - 200
publisher
Elsevier
external identifiers
  • scopus:84992184119
ISSN
0278-6915
DOI
10.1016/j.fct.2016.09.032
language
English
LU publication?
no
id
ca9fefcc-28a0-411c-b0d9-984eee1d9bd6
date added to LUP
2016-12-12 11:41:00
date last changed
2017-03-30 14:50:44
@article{ca9fefcc-28a0-411c-b0d9-984eee1d9bd6,
  abstract     = {<p>Summary: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE &gt; 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE &gt; 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2).</p>},
  author       = {Api, A. M. and Belsito, D. and Bhatia, S. and Bruze, M. and Calow, P. and Dagli, M. L. and Dekant, W. and Fryer, A. D. and Kromidas, L. and La Cava, S. and Lalko, J. F. and Lapczynski, A. and Liebler, D. C. and Politano, V. T. and Ritacco, G. and Salvito, D. and Schultz, T. W. and Shen, J. and Sipes, I. G. and Wall, B. and Wilcox, D. K.},
  issn         = {0278-6915},
  keyword      = {Developmental and reproductive toxicity,Environmental safety,Genotoxicity,Local respiratory toxicity,Phototoxicity/photoallergenicity,Repeated dose,Skin sensitization},
  language     = {eng},
  month        = {11},
  pages        = {192--200},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3},
  url          = {http://dx.doi.org/10.1016/j.fct.2016.09.032},
  volume       = {97},
  year         = {2016},
}