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Long-Term Risk of Hospitalization for Somatic Diseases among Survivors of Childhood Acute Lymphoblastic Leukemia

Sørensen, Gitte Vrelits ; Albieri, Vanna ; Holmqvist, Anna Sällfors LU ; Erdmann, Friederike ; Mogensen, Hanna ; Talbäck, Mats ; Ifversen, Marianne ; Lash, Timothy Lee ; Feychting, Maria and Schmiegelow, Kjeld , et al. (2022) In JNCI Cancer Spectrum 6(2).
Abstract

Background: Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods: Danish and Swedish patients diagnosed with ALL before age 20 years in 1982-2008 were identified in the national cancer registries. Five-year survivors and matched population comparisons without childhood cancer were followed for hospitalization for 120 somatic disease categories in the national hospital registries from 5 years postdiagnosis until 2017, and disease-specific... (More)

Background: Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods: Danish and Swedish patients diagnosed with ALL before age 20 years in 1982-2008 were identified in the national cancer registries. Five-year survivors and matched population comparisons without childhood cancer were followed for hospitalization for 120 somatic disease categories in the national hospital registries from 5 years postdiagnosis until 2017, and disease-specific hospitalization rate ratios (RR) were calculated. The mean cumulative count method was used to estimate the mean number of multiple and recurrent disease-specific hospitalizations per individual. Results: A total of 2024 5-year survivors and 9797 population comparisons were included. The overall hospitalization rate was more than twice as high compared with comparisons (RR = 2.30, 95% confidence interval [CI] = 2.09 to 2.52). At 30 years postdiagnosis, the mean cumulative hospitalization count was 1.69 (95% CI = 1.47 to 1.90) per survivor and 0.80 (95% CI = 0.73 to 0.86) per comparison. In the subcohort without relapse or HSCT (n = 1709), the RR was 1.41 (95% CI = 1.27 to 1.58). Conclusions: Survivors of childhood ALL were at increased long-term risk for disease-specific hospitalizations; however, in survivors without relapse or HSCT, the rate was only modestly higher than in population comparisons without a childhood cancer. The absolute mean numbers of multiple and recurrent hospitalizations were generally low.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
JNCI Cancer Spectrum
volume
6
issue
2
article number
pkac029
publisher
Oxford University Press
external identifiers
  • pmid:35603856
  • scopus:85136910639
ISSN
2515-5091
DOI
10.1093/jncics/pkac029
language
English
LU publication?
yes
id
cb02d2aa-bcb0-4e76-a1c2-a04f4340d5f3
date added to LUP
2022-10-25 15:37:34
date last changed
2024-03-21 08:09:26
@article{cb02d2aa-bcb0-4e76-a1c2-a04f4340d5f3,
  abstract     = {{<p>Background: Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods: Danish and Swedish patients diagnosed with ALL before age 20 years in 1982-2008 were identified in the national cancer registries. Five-year survivors and matched population comparisons without childhood cancer were followed for hospitalization for 120 somatic disease categories in the national hospital registries from 5 years postdiagnosis until 2017, and disease-specific hospitalization rate ratios (RR) were calculated. The mean cumulative count method was used to estimate the mean number of multiple and recurrent disease-specific hospitalizations per individual. Results: A total of 2024 5-year survivors and 9797 population comparisons were included. The overall hospitalization rate was more than twice as high compared with comparisons (RR = 2.30, 95% confidence interval [CI] = 2.09 to 2.52). At 30 years postdiagnosis, the mean cumulative hospitalization count was 1.69 (95% CI = 1.47 to 1.90) per survivor and 0.80 (95% CI = 0.73 to 0.86) per comparison. In the subcohort without relapse or HSCT (n = 1709), the RR was 1.41 (95% CI = 1.27 to 1.58). Conclusions: Survivors of childhood ALL were at increased long-term risk for disease-specific hospitalizations; however, in survivors without relapse or HSCT, the rate was only modestly higher than in population comparisons without a childhood cancer. The absolute mean numbers of multiple and recurrent hospitalizations were generally low.</p>}},
  author       = {{Sørensen, Gitte Vrelits and Albieri, Vanna and Holmqvist, Anna Sällfors and Erdmann, Friederike and Mogensen, Hanna and Talbäck, Mats and Ifversen, Marianne and Lash, Timothy Lee and Feychting, Maria and Schmiegelow, Kjeld and Heyman, Mats Marshall and Winther, Jeanette Falck and Hasle, Henrik}},
  issn         = {{2515-5091}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Oxford University Press}},
  series       = {{JNCI Cancer Spectrum}},
  title        = {{Long-Term Risk of Hospitalization for Somatic Diseases among Survivors of Childhood Acute Lymphoblastic Leukemia}},
  url          = {{http://dx.doi.org/10.1093/jncics/pkac029}},
  doi          = {{10.1093/jncics/pkac029}},
  volume       = {{6}},
  year         = {{2022}},
}