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Pathogenesis of immune thrombocytopenia

Cines, Douglas B; Cuker, Adam and Semple, John W LU (2014) In Presse médicale (Paris, France : 1983) 43(4 Pt 2). p.49-59
Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction. The platelet, as an accessible target, has made ITP an attractive disorder in the study of autoimmunity. However, the pathogenesis of ITP has proven complex with diverse pre-existing challenges to the immune system in the form of infection, genetic predisposition, underlying autoimmune repertoire, inhibition of platelet production, perturbations of cell mediated affector and effector pathways, sequestered harbors within lymphoid organs, and responsiveness to intervention. This chapter surveys key new insights into the pathogenesis of ITP and attempts to integrate them into a model that may serve as a template for future... (More)

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction. The platelet, as an accessible target, has made ITP an attractive disorder in the study of autoimmunity. However, the pathogenesis of ITP has proven complex with diverse pre-existing challenges to the immune system in the form of infection, genetic predisposition, underlying autoimmune repertoire, inhibition of platelet production, perturbations of cell mediated affector and effector pathways, sequestered harbors within lymphoid organs, and responsiveness to intervention. This chapter surveys key new insights into the pathogenesis of ITP and attempts to integrate them into a model that may serve as a template for future investigation.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Humans, Purpura, Thrombocytopenic, Idiopathic, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
in
Presse médicale (Paris, France : 1983)
volume
43
issue
4 Pt 2
pages
49 - 59
publisher
Elsevier Masson
external identifiers
  • scopus:84898906233
ISSN
0755-4982
DOI
10.1016/j.lpm.2014.01.010
language
English
LU publication?
no
id
cb09b494-de01-4b65-a1de-57189757238e
date added to LUP
2016-09-23 12:01:09
date last changed
2017-07-09 04:53:18
@misc{cb09b494-de01-4b65-a1de-57189757238e,
  abstract     = {<p>Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction. The platelet, as an accessible target, has made ITP an attractive disorder in the study of autoimmunity. However, the pathogenesis of ITP has proven complex with diverse pre-existing challenges to the immune system in the form of infection, genetic predisposition, underlying autoimmune repertoire, inhibition of platelet production, perturbations of cell mediated affector and effector pathways, sequestered harbors within lymphoid organs, and responsiveness to intervention. This chapter surveys key new insights into the pathogenesis of ITP and attempts to integrate them into a model that may serve as a template for future investigation.</p>},
  author       = {Cines, Douglas B and Cuker, Adam and Semple, John W},
  issn         = {0755-4982},
  keyword      = {Humans,Purpura, Thrombocytopenic, Idiopathic,Journal Article,Research Support, N.I.H., Extramural,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {4 Pt 2},
  pages        = {49--59},
  publisher    = {Elsevier Masson},
  series       = {Presse médicale (Paris, France : 1983)},
  title        = {Pathogenesis of immune thrombocytopenia},
  url          = {http://dx.doi.org/10.1016/j.lpm.2014.01.010},
  volume       = {43},
  year         = {2014},
}