Advanced

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Michaud, Dominique S.; Izard, Jacques; Wilhelm-Benartzi, Charlotte S.; You, Doo-Ho; Grote, Verena A.; Tjonneland, Anne; Dahm, Christina C.; Overvad, Kim; Jenab, Mazda and Fedirko, Veronika, et al. (2013) In Gut 62(12). p.1764-1770
Abstract
Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36;... (More)
Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200ng/ml vs 200ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pancreatic Cancer, Epidemiology, Bacterial Pathogenesis
in
Gut
volume
62
issue
12
pages
1764 - 1770
publisher
BMJ Publishing Group
external identifiers
  • wos:000326877200014
  • scopus:84887615482
ISSN
1468-3288
DOI
10.1136/gutjnl-2012-303006
language
English
LU publication?
yes
id
cb2802ac-4204-46e9-980f-a6355a16c123 (old id 4196547)
date added to LUP
2014-01-02 12:22:26
date last changed
2019-05-19 04:05:50
@article{cb2802ac-4204-46e9-980f-a6355a16c123,
  abstract     = {Objective Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200ng/ml vs 200ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.},
  author       = {Michaud, Dominique S. and Izard, Jacques and Wilhelm-Benartzi, Charlotte S. and You, Doo-Ho and Grote, Verena A. and Tjonneland, Anne and Dahm, Christina C. and Overvad, Kim and Jenab, Mazda and Fedirko, Veronika and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Franoise and Racine, Antoine and Kaaks, Rudolf and Boeing, Heiner and Foerster, Jana and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Sacerdote, Carlotta and Sieri, Sabina and Palli, Domenico and Tumino, Rosario and Panico, Salvatore and Siersema, Peter D. and Peeters, Petra H. M. and Lund, Eiliv and Barricarte, Aurelio and Huerta, Jose-Maria and Molina-Montes, Esther and Dorronsoro, Miren and Ramon Quiros, J. and Duell, Eric J. and Ye, Weimin and Sund, Malin and Lindkvist, Bjorn and Johansen, Dorthe and Khaw, Kay-Tee and Wareham, Nick and Travis, Ruth C. and Vineis, Paolo and Bueno-de-Mesquita, H. Bas and Riboli, Elio},
  issn         = {1468-3288},
  keyword      = {Pancreatic Cancer,Epidemiology,Bacterial Pathogenesis},
  language     = {eng},
  number       = {12},
  pages        = {1764--1770},
  publisher    = {BMJ Publishing Group},
  series       = {Gut},
  title        = {Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study},
  url          = {http://dx.doi.org/10.1136/gutjnl-2012-303006},
  volume       = {62},
  year         = {2013},
}