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Vesicular drug delivery for the treatment of topical disorders : current and future perspectives

Witika, Bwalya A. ; Mweetwa, Larry L. ; Tshiamo, Kabo O. ; Edler, Karen LU orcid ; Matafwali, Scott K. ; Ntemi, Pascal V. ; Chikukwa, Melissa T.R. and Makoni, Pedzisai A. (2021) In The Journal of pharmacy and pharmacology 73(11). p.1427-1441
Abstract

OBJECTIVES: Vesicular drug delivery has become a useful approach for therapeutic administration of pharmaceutical compounds. Lipid vesicles have found application in membrane biology, immunology, genetic engineering and theragnostics. This review summarizes topical delivery, specifically dermal/transdermal, ocular and transungual, via these vesicles, including future formulation perspectives.

KEY FINDINGS: Liposomes and their subsequent derivatives, viz. niosomes, transferosomes, pharmacososmes and ethosomes, form a significant part of vesicular systems that have been successfully utilized in treating an array of topical disorders. These vesicles are thought to be a safe and effective mode of improving the delivery of... (More)

OBJECTIVES: Vesicular drug delivery has become a useful approach for therapeutic administration of pharmaceutical compounds. Lipid vesicles have found application in membrane biology, immunology, genetic engineering and theragnostics. This review summarizes topical delivery, specifically dermal/transdermal, ocular and transungual, via these vesicles, including future formulation perspectives.

KEY FINDINGS: Liposomes and their subsequent derivatives, viz. niosomes, transferosomes, pharmacososmes and ethosomes, form a significant part of vesicular systems that have been successfully utilized in treating an array of topical disorders. These vesicles are thought to be a safe and effective mode of improving the delivery of lipophilic and hydrophilic drugs.

SUMMARY: Several drug molecules are available for topical disorders. However, physicochemical properties and undesirable toxicity have limited their efficacy. Vesicular delivery systems have the potential to overcome these shortcomings due to properties such as high biocompatibility, simplicity of surface modification and suitability as controlled delivery vehicles. However, incorporating these systems into environmentally responsive dispersants such as hydrogels, ionic liquids and deep eutectic solvents may further enhance therapeutic prowess of these delivery systems. Consequently, improved vesicular drug delivery can be achieved by considering combining some of these formulation approaches.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dermal, liposomes, ocular, topical disorders, transungual, vesicular drug delivery
in
The Journal of pharmacy and pharmacology
volume
73
issue
11
pages
15 pages
publisher
Oxford University Press
external identifiers
  • pmid:34132342
  • scopus:85113753679
ISSN
0022-3573
DOI
10.1093/jpp/rgab082
language
English
LU publication?
no
additional info
Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society.
id
cb2ef408-17c3-4d6c-af14-379b9a591dca
date added to LUP
2022-07-12 15:36:25
date last changed
2024-04-16 06:56:49
@article{cb2ef408-17c3-4d6c-af14-379b9a591dca,
  abstract     = {{<p>OBJECTIVES: Vesicular drug delivery has become a useful approach for therapeutic administration of pharmaceutical compounds. Lipid vesicles have found application in membrane biology, immunology, genetic engineering and theragnostics. This review summarizes topical delivery, specifically dermal/transdermal, ocular and transungual, via these vesicles, including future formulation perspectives. <br/></p><p>KEY FINDINGS: Liposomes and their subsequent derivatives, viz. niosomes, transferosomes, pharmacososmes and ethosomes, form a significant part of vesicular systems that have been successfully utilized in treating an array of topical disorders. These vesicles are thought to be a safe and effective mode of improving the delivery of lipophilic and hydrophilic drugs. <br/></p><p>SUMMARY: Several drug molecules are available for topical disorders. However, physicochemical properties and undesirable toxicity have limited their efficacy. Vesicular delivery systems have the potential to overcome these shortcomings due to properties such as high biocompatibility, simplicity of surface modification and suitability as controlled delivery vehicles. However, incorporating these systems into environmentally responsive dispersants such as hydrogels, ionic liquids and deep eutectic solvents may further enhance therapeutic prowess of these delivery systems. Consequently, improved vesicular drug delivery can be achieved by considering combining some of these formulation approaches.</p>}},
  author       = {{Witika, Bwalya A. and Mweetwa, Larry L. and Tshiamo, Kabo O. and Edler, Karen and Matafwali, Scott K. and Ntemi, Pascal V. and Chikukwa, Melissa T.R. and Makoni, Pedzisai A.}},
  issn         = {{0022-3573}},
  keywords     = {{dermal; liposomes; ocular; topical disorders; transungual; vesicular drug delivery}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{11}},
  pages        = {{1427--1441}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of pharmacy and pharmacology}},
  title        = {{Vesicular drug delivery for the treatment of topical disorders : current and future perspectives}},
  url          = {{http://dx.doi.org/10.1093/jpp/rgab082}},
  doi          = {{10.1093/jpp/rgab082}},
  volume       = {{73}},
  year         = {{2021}},
}