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Short-term effect of pharmacologically induced alterations in testosterone levels on common blood biomarkers in a controlled healthy human model

Sahlin, K. Barbara LU ; Pla, Indira LU ; Sanchez, Aniel LU ; Pawłowski, Krzysztof LU ; Leijonhufvud, Irene LU ; Appelqvist, Roger LU ; Marko-Varga, György LU ; Giwercman, Aleksander LU and Malm, Johan LU (2020) In Scandinavian Journal of Clinical and Laboratory Investigation 80(1). p.25-31
Abstract

Testosterone deficiency in males is associated with serious comorbidities such as cardiovascular disease, diabetes type two, and also an increased risk of premature death. The pathogenetic mechanism behind this association, however, has not yet been clarified and is potentially bidirectional. The aim of this clinical trial was to gain insight into the short-term effect of changes in testosterone on blood analytes in healthy young men. Thirty healthy young male volunteers were recruited and monitored in our designed human model. Blood sampling was performed prior to and 3 weeks after pharmacological castration with a gonadotropin-releasing hormone antagonist. Subsequently, testosterone replacement with 1000 mg testosterone undecanoate... (More)

Testosterone deficiency in males is associated with serious comorbidities such as cardiovascular disease, diabetes type two, and also an increased risk of premature death. The pathogenetic mechanism behind this association, however, has not yet been clarified and is potentially bidirectional. The aim of this clinical trial was to gain insight into the short-term effect of changes in testosterone on blood analytes in healthy young men. Thirty healthy young male volunteers were recruited and monitored in our designed human model. Blood sampling was performed prior to and 3 weeks after pharmacological castration with a gonadotropin-releasing hormone antagonist. Subsequently, testosterone replacement with 1000 mg testosterone undecanoate was given and additional blood samples were collected 2 weeks later. The alterations in the levels of 37 routine biomarkers were statistically analysed. Eight biomarkers changed significantly in a similar manner as testosterone between the time points (e.g. prostate specific antigen, creatinine and magnesium), whereas seven other markers changed in the inverse manner as testosterone, including sexual hormone-binding globulin, urea, aspartate aminotransferase and alanine aminotransferase. Most of our results were supported by data from other studies. The designed controlled human model yielded changes in known biomarkers suggesting that low testosterone has a negative effect on health in young healthy men.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
comorbidities, gonadotropin-releasing hormone, gonadotropins, healthy males, hormone antagonists, hypogonadism, reproduction, Testosterone
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
80
issue
1
pages
7 pages
publisher
Informa Healthcare
external identifiers
  • pmid:31738571
  • scopus:85075239986
ISSN
0036-5513
DOI
10.1080/00365513.2019.1689429
language
English
LU publication?
yes
id
cb642944-b8a9-408e-86f6-42f7550bb4cf
date added to LUP
2019-12-06 13:54:24
date last changed
2020-03-16 11:58:23
@article{cb642944-b8a9-408e-86f6-42f7550bb4cf,
  abstract     = {<p>Testosterone deficiency in males is associated with serious comorbidities such as cardiovascular disease, diabetes type two, and also an increased risk of premature death. The pathogenetic mechanism behind this association, however, has not yet been clarified and is potentially bidirectional. The aim of this clinical trial was to gain insight into the short-term effect of changes in testosterone on blood analytes in healthy young men. Thirty healthy young male volunteers were recruited and monitored in our designed human model. Blood sampling was performed prior to and 3 weeks after pharmacological castration with a gonadotropin-releasing hormone antagonist. Subsequently, testosterone replacement with 1000 mg testosterone undecanoate was given and additional blood samples were collected 2 weeks later. The alterations in the levels of 37 routine biomarkers were statistically analysed. Eight biomarkers changed significantly in a similar manner as testosterone between the time points (e.g. prostate specific antigen, creatinine and magnesium), whereas seven other markers changed in the inverse manner as testosterone, including sexual hormone-binding globulin, urea, aspartate aminotransferase and alanine aminotransferase. Most of our results were supported by data from other studies. The designed controlled human model yielded changes in known biomarkers suggesting that low testosterone has a negative effect on health in young healthy men.</p>},
  author       = {Sahlin, K. Barbara and Pla, Indira and Sanchez, Aniel and Pawłowski, Krzysztof and Leijonhufvud, Irene and Appelqvist, Roger and Marko-Varga, György and Giwercman, Aleksander and Malm, Johan},
  issn         = {0036-5513},
  language     = {eng},
  number       = {1},
  pages        = {25--31},
  publisher    = {Informa Healthcare},
  series       = {Scandinavian Journal of Clinical and Laboratory Investigation},
  title        = {Short-term effect of pharmacologically induced alterations in testosterone levels on common blood biomarkers in a controlled healthy human model},
  url          = {http://dx.doi.org/10.1080/00365513.2019.1689429},
  doi          = {10.1080/00365513.2019.1689429},
  volume       = {80},
  year         = {2020},
}