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Cardiac metabolism measured noninvasively by hyperpolarized (13)C MRI.

Golman, Klaes LU ; Petersson, J Stefan ; Magnusson, Peter ; Johansson, Edvin LU ; Åkeson, Per LU ; Chai, Chun-Ming LU ; Hansson, Georg and Månsson, Sven LU (2008) In Magnetic Resonance in Medicine 59(5). p.1005-1013
Abstract
Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29-34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by (13)C chemical shift imaging following intravenous injection of 1-(13)C pyruvate. (13)C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area... (More)
Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29-34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by (13)C chemical shift imaging following intravenous injection of 1-(13)C pyruvate. (13)C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area was reduced (25-44%) compared with the normal myocardium. Alanine signal level was normal. After a 45-min occlusion (infarction) the bicarbonate signal was almost absent (0.2-11%) and the alanine signal was reduced (27-51%). Due to image-folding artifacts the data obtained for lactate were inconclusive. These studies demonstrate that cardiac metabolic imaging with hyperpolarized 1-(13)C-pyruvate is feasible. The changes in concentrations of the metabolites within a minute after injection can be detected and metabolic maps constructed. Magn Reson Med 59:1005-1013, 2008. (c) 2008 Wiley-Liss, Inc. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance in Medicine
volume
59
issue
5
pages
1005 - 1013
publisher
John Wiley and Sons
external identifiers
  • wos:000255230700009
  • pmid:18429038
  • scopus:42549171517
  • pmid:18429038
ISSN
1522-2594
DOI
10.1002/mrm.21460
language
English
LU publication?
yes
id
cb7391c3-71a8-4f67-a0fc-7e5dc2ad76ac (old id 1147135)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18429038?dopt=Abstract
date added to LUP
2016-04-04 08:44:45
date last changed
2021-01-12 03:02:02
@article{cb7391c3-71a8-4f67-a0fc-7e5dc2ad76ac,
  abstract     = {Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29-34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by (13)C chemical shift imaging following intravenous injection of 1-(13)C pyruvate. (13)C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area was reduced (25-44%) compared with the normal myocardium. Alanine signal level was normal. After a 45-min occlusion (infarction) the bicarbonate signal was almost absent (0.2-11%) and the alanine signal was reduced (27-51%). Due to image-folding artifacts the data obtained for lactate were inconclusive. These studies demonstrate that cardiac metabolic imaging with hyperpolarized 1-(13)C-pyruvate is feasible. The changes in concentrations of the metabolites within a minute after injection can be detected and metabolic maps constructed. Magn Reson Med 59:1005-1013, 2008. (c) 2008 Wiley-Liss, Inc.},
  author       = {Golman, Klaes and Petersson, J Stefan and Magnusson, Peter and Johansson, Edvin and Åkeson, Per and Chai, Chun-Ming and Hansson, Georg and Månsson, Sven},
  issn         = {1522-2594},
  language     = {eng},
  number       = {5},
  pages        = {1005--1013},
  publisher    = {John Wiley and Sons},
  series       = {Magnetic Resonance in Medicine},
  title        = {Cardiac metabolism measured noninvasively by hyperpolarized (13)C MRI.},
  url          = {http://dx.doi.org/10.1002/mrm.21460},
  doi          = {10.1002/mrm.21460},
  volume       = {59},
  year         = {2008},
}