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Cerebrospinal fluid biomarkers for the diagnosis and prognosis of Parkinson's disease : protocol for a systematic review and individual participant data meta-analysis

Eusebi, Paolo ; Hansson, Oskar LU orcid ; Paciotti, Silvia ; Orso, Massimiliano ; Chiasserini, Davide ; Calabresi, Paolo ; Blennow, Kaj LU and Parnetti, Lucilla (2017) In BMJ Open 7(11). p.018177-018177
Abstract

INTRODUCTION: Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder related to α-synuclein misfolding and aggregation. For this reason, it belongs to the family of 'synucleinopathies', which also includes some other neurological diseases. Although imaging and ancillary investigations may be helpful in the diagnostic workup, the diagnosis of PD mostly relies on the clinician's expertise. Furthermore, there is a need today for markers that can track the disease progression in PD that might improve the evaluation of novel disease-modifying therapies. The cerebrospinal fluid (CSF) has been widely investigated with the purpose of finding useful diagnostic and prognostic biomarkers for PD.

METHODS AND ANALYSIS:... (More)

INTRODUCTION: Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder related to α-synuclein misfolding and aggregation. For this reason, it belongs to the family of 'synucleinopathies', which also includes some other neurological diseases. Although imaging and ancillary investigations may be helpful in the diagnostic workup, the diagnosis of PD mostly relies on the clinician's expertise. Furthermore, there is a need today for markers that can track the disease progression in PD that might improve the evaluation of novel disease-modifying therapies. The cerebrospinal fluid (CSF) has been widely investigated with the purpose of finding useful diagnostic and prognostic biomarkers for PD.

METHODS AND ANALYSIS: This systematic review protocol has been developed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocol 2015 statement and was registered on the PROSPERO international prospective register of systematic reviews. An international collaboration will be established. We will search the Cochrane Library, Web of Science, Medline and Embase from inception, using appropriate search strategies. Individual participant data from all included studies will be merged into a single database. We will include any study assessing the diagnostic and prognostic role of CSF biomarkers in PD. To evaluate the risk of bias and applicability of primary diagnostic accuracy studies, we will use Quality Assessment of Diagnostic Accuracy Studies-2 and Quality in Prognostic Studies. We will use standard meta-analytic procedures. We will first explore the utility of each CSF biomarker in turn. For each biomarker, we will assess its diagnostic and prognostic utility by means of receiver operating characteristic analysis and regression models. We will then move towards a multivariate approach considering different panels of biomarkers.

ETHICS AND DISSEMINATION: Our study will not include confidential data, and no intervention will be involved, so ethical approval is not required. The results of the study will be reported in international peer-reviewed journals.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebrospinal fluid, diagnosis, meta-analysis, Parkinson’s disease, prognosis
in
BMJ Open
volume
7
issue
11
pages
018177 - 018177
publisher
BMJ Publishing Group
external identifiers
  • pmid:29170290
  • scopus:85049408379
ISSN
2044-6055
DOI
10.1136/bmjopen-2017-018177
language
English
LU publication?
yes
id
cb75e3da-d04d-4e04-8b8c-a9561c9f0f1d
date added to LUP
2018-07-19 11:42:41
date last changed
2024-07-08 16:38:47
@article{cb75e3da-d04d-4e04-8b8c-a9561c9f0f1d,
  abstract     = {{<p>INTRODUCTION: Idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder related to α-synuclein misfolding and aggregation. For this reason, it belongs to the family of 'synucleinopathies', which also includes some other neurological diseases. Although imaging and ancillary investigations may be helpful in the diagnostic workup, the diagnosis of PD mostly relies on the clinician's expertise. Furthermore, there is a need today for markers that can track the disease progression in PD that might improve the evaluation of novel disease-modifying therapies. The cerebrospinal fluid (CSF) has been widely investigated with the purpose of finding useful diagnostic and prognostic biomarkers for PD.</p><p>METHODS AND ANALYSIS: This systematic review protocol has been developed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocol 2015 statement and was registered on the PROSPERO international prospective register of systematic reviews. An international collaboration will be established. We will search the Cochrane Library, Web of Science, Medline and Embase from inception, using appropriate search strategies. Individual participant data from all included studies will be merged into a single database. We will include any study assessing the diagnostic and prognostic role of CSF biomarkers in PD. To evaluate the risk of bias and applicability of primary diagnostic accuracy studies, we will use Quality Assessment of Diagnostic Accuracy Studies-2 and Quality in Prognostic Studies. We will use standard meta-analytic procedures. We will first explore the utility of each CSF biomarker in turn. For each biomarker, we will assess its diagnostic and prognostic utility by means of receiver operating characteristic analysis and regression models. We will then move towards a multivariate approach considering different panels of biomarkers.</p><p>ETHICS AND DISSEMINATION: Our study will not include confidential data, and no intervention will be involved, so ethical approval is not required. The results of the study will be reported in international peer-reviewed journals.</p>}},
  author       = {{Eusebi, Paolo and Hansson, Oskar and Paciotti, Silvia and Orso, Massimiliano and Chiasserini, Davide and Calabresi, Paolo and Blennow, Kaj and Parnetti, Lucilla}},
  issn         = {{2044-6055}},
  keywords     = {{cerebrospinal fluid; diagnosis; meta-analysis; Parkinson’s disease; prognosis}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  pages        = {{018177--018177}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Cerebrospinal fluid biomarkers for the diagnosis and prognosis of Parkinson's disease : protocol for a systematic review and individual participant data meta-analysis}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2017-018177}},
  doi          = {{10.1136/bmjopen-2017-018177}},
  volume       = {{7}},
  year         = {{2017}},
}