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A genetic linkage map of the laboratory rat, Rattus norvegicus

Jacob, Howard J. ; Brown, Donna M. ; Bunker, Ruth K. ; Daly, Mark J. LU ; Dzau, Victor J. ; Goodman, Alec ; Koike, George ; Kren, Vladimir ; Kurtz, Theodore and Lernmark, Åke LU orcid , et al. (1995) In Nature Genetics 9(1). p.63-69
Abstract

We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR × BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative... (More)

We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR × BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.

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publishing date
type
Contribution to journal
publication status
published
in
Nature Genetics
volume
9
issue
1
pages
63 - 69
publisher
Nature Publishing Group
external identifiers
  • scopus:0028894556
  • pmid:7704027
ISSN
1061-4036
DOI
10.1038/ng0195-63
language
English
LU publication?
no
id
cb92503a-091f-4fdd-be8d-0c7dd67bed0f
date added to LUP
2019-09-11 08:59:13
date last changed
2024-06-13 03:14:06
@article{cb92503a-091f-4fdd-be8d-0c7dd67bed0f,
  abstract     = {{<p>We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR × BN) F<sub>2</sub> intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.</p>}},
  author       = {{Jacob, Howard J. and Brown, Donna M. and Bunker, Ruth K. and Daly, Mark J. and Dzau, Victor J. and Goodman, Alec and Koike, George and Kren, Vladimir and Kurtz, Theodore and Lernmark, Åke and Levan, Göran and Mao, Yi pei and Pettersson, Anna and Pravenec, Michal and Simon, Jason S. and Szpirer, Claude and Szpirer, Josiane and Trolliet, Maria R. and Winer, Eric S. and Lander, Eric S.}},
  issn         = {{1061-4036}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{63--69}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Genetics}},
  title        = {{A genetic linkage map of the laboratory rat, Rattus norvegicus}},
  url          = {{http://dx.doi.org/10.1038/ng0195-63}},
  doi          = {{10.1038/ng0195-63}},
  volume       = {{9}},
  year         = {{1995}},
}