Expression and clinical significance of DNA helicase RecQL1 in cervical cancer and its precancerous lesions
Wu, Lin ; Yang, Hui ; Gao, Xiaojia ; Wang, Qiaoli LU
; Yang, Lei
; Zhou, Fuxiang
and Zhou, Yunfeng
(2015)
In Medical Journal of Wuhan University
36(4).
- Abstract
Objective: To investigate the expression and clinical significance of DNA helicase RecQL1 in cervical carcinoma and cervical intraepithelial neoplasia(CIN). Methods: The expression of DNA helicase RecQL1 were determined with reference to clinicopathological features and patient survival. 75 cervical carcinoma, 60 CIN and 20 normal control cases were collected for immunohistochemical analysis. Results: The expression rate of RecQL1 in the normal cervix, CIN and cervical carcinoma was 10.000%(2/20), 55.000%(33/60), and 74.700%(55/75), respectively, with a significant difference between them (P<0.05). In the 75 cervical carcinoma cases, the positive rate of RecQL1 in the cases with lymph node metastasis and negative lymph nodes was... (More)
Objective: To investigate the expression and clinical significance of DNA helicase RecQL1 in cervical carcinoma and cervical intraepithelial neoplasia(CIN). Methods: The expression of DNA helicase RecQL1 were determined with reference to clinicopathological features and patient survival. 75 cervical carcinoma, 60 CIN and 20 normal control cases were collected for immunohistochemical analysis. Results: The expression rate of RecQL1 in the normal cervix, CIN and cervical carcinoma was 10.000%(2/20), 55.000%(33/60), and 74.700%(55/75), respectively, with a significant difference between them (P<0.05). In the 75 cervical carcinoma cases, the positive rate of RecQL1 in the cases with lymph node metastasis and negative lymph nodes was 89.300% and 63.800%, respectively, with a significant difference between the two subgroups(P<0.05). Among the 75 followed-up cervical carcinoma patients, the RecQL1+ and RecQL1- cases had an overall survival of (42.000±20.762) months and (115.990±13.593) months, respectively, with a significant difference between them(P<0.001). The multivariate analysis showed that RecQL1 expression, lymph node metastasis and tumor staging were independent prognostic factors. Conclusion: RecQL1 proteins may play important roles in the occurrence and development of cervical carcinoma. There is a close relationship between the expression of RecQL1 proteins and the prognosis of cervical carcinoma patients.
(Less)
- author
- Wu, Lin
; Yang, Hui
; Gao, Xiaojia
; Wang, Qiaoli
LU
; Yang, Lei
; Zhou, Fuxiang
and Zhou, Yunfeng
- publishing date
- 2015-07-15
- type
- Contribution to journal
- publication status
- published
- keywords
- Cervical intraepithelial neoplasms, DNA Helicase RecQL1, Immunohistochemistry, Uterine cervical neoplasms
- in
- Medical Journal of Wuhan University
- volume
- 36
- issue
- 4
- publisher
- Editorial Board of Medical Journal of Wuhan University
- external identifiers
-
- scopus:84945422614
- ISSN
- 1671-8852
- DOI
- 10.14188/j.1671-8852.2015.04.002
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: ©, 2015, Editorial Board of Medical Journal of Wuhan University. All right reserved.
- id
- cb9e78dd-efce-4973-ae40-dba85e0cd1b6
- date added to LUP
- 2025-10-17 12:15:04
- date last changed
- 2025-10-20 08:01:56
@article{cb9e78dd-efce-4973-ae40-dba85e0cd1b6,
abstract = {{<p>Objective: To investigate the expression and clinical significance of DNA helicase RecQL1 in cervical carcinoma and cervical intraepithelial neoplasia(CIN). Methods: The expression of DNA helicase RecQL1 were determined with reference to clinicopathological features and patient survival. 75 cervical carcinoma, 60 CIN and 20 normal control cases were collected for immunohistochemical analysis. Results: The expression rate of RecQL1 in the normal cervix, CIN and cervical carcinoma was 10.000%(2/20), 55.000%(33/60), and 74.700%(55/75), respectively, with a significant difference between them (P<0.05). In the 75 cervical carcinoma cases, the positive rate of RecQL1 in the cases with lymph node metastasis and negative lymph nodes was 89.300% and 63.800%, respectively, with a significant difference between the two subgroups(P<0.05). Among the 75 followed-up cervical carcinoma patients, the RecQL1<sup>+</sup> and RecQL1<sup>-</sup> cases had an overall survival of (42.000±20.762) months and (115.990±13.593) months, respectively, with a significant difference between them(P<0.001). The multivariate analysis showed that RecQL1 expression, lymph node metastasis and tumor staging were independent prognostic factors. Conclusion: RecQL1 proteins may play important roles in the occurrence and development of cervical carcinoma. There is a close relationship between the expression of RecQL1 proteins and the prognosis of cervical carcinoma patients.</p>}},
author = {{Wu, Lin and Yang, Hui and Gao, Xiaojia and Wang, Qiaoli and Yang, Lei and Zhou, Fuxiang and Zhou, Yunfeng}},
issn = {{1671-8852}},
keywords = {{Cervical intraepithelial neoplasms; DNA Helicase RecQL1; Immunohistochemistry; Uterine cervical neoplasms}},
language = {{eng}},
month = {{07}},
number = {{4}},
publisher = {{Editorial Board of Medical Journal of Wuhan University}},
series = {{Medical Journal of Wuhan University}},
title = {{Expression and clinical significance of DNA helicase RecQL1 in cervical cancer and its precancerous lesions}},
url = {{http://dx.doi.org/10.14188/j.1671-8852.2015.04.002}},
doi = {{10.14188/j.1671-8852.2015.04.002}},
volume = {{36}},
year = {{2015}},
}