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Time to onset of improvements in Quality of Life from Temperature-controlled Laminar Airflow (TLA) in severe allergic asthma

Bjermer, L. LU ; Eriksson, G. LU ; Radner, F. LU orcid ; Peterson, Stefan LU and Warner, J. O. (2019) In Respiratory Medicine 147. p.19-25
Abstract

Background: Allergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA; Airsonett®) has been shown to provide significant reduction of exposure to allergens in the breathing zone, leading to long-term reduction in airway inflammation and improvement in quality of life. Allergic asthma patients uncontrolled on GINA step 4 were found to benefit the most. A frequently asked question from clinicians and funders is related to time to onset (TTO) of improvements for patients using TLA. Methods: Asthma Quality of Life Questionnaire (AQLQ) scores were collected in a previous study. TTO of improvements in Quality of Life was analysed for difference (TLA-placebo)... (More)

Background: Allergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA; Airsonett®) has been shown to provide significant reduction of exposure to allergens in the breathing zone, leading to long-term reduction in airway inflammation and improvement in quality of life. Allergic asthma patients uncontrolled on GINA step 4 were found to benefit the most. A frequently asked question from clinicians and funders is related to time to onset (TTO) of improvements for patients using TLA. Methods: Asthma Quality of Life Questionnaire (AQLQ) scores were collected in a previous study. TTO of improvements in Quality of Life was analysed for difference (TLA-placebo) in Area-under-Curve using backwards deletion from 12, 9, 6, 3 down to 1 month for the AQLQ total score, the four individual domains and specifically the sleep question. Results: Patients with uncontrolled asthma on GINA step 4 (n = 87)) reported a statistically significant and clinically relevant (≥0.5 point) improvement in total AQLQ score (0.57; p = 0.009) after 3 months treatment for TLA over placebo. The shortest TTO was within 1 month for the environmental domain (0.68; p = 0.016) and the sleep question (0.771; p = 0.037). TTO for the emotional and symptom domains was 3 months (0.66; p = 0.020 and 0.64; p = 0.014 respectively) and for the activity domain 6 months (0.47; p = 0.036). Conclusion: Nocturnal avoidance of allergens using TLA provided a statistically significant and clinically relevant improvement in total AQLQ score within 3 months in patients in the GINA 4 + ACT<18 group. Questions related to sleep quality may provide the first signal of response already within a month after commencing treatment.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Allergen avoidance, AQLQ, Quality of Life, Severe allergic asthma, Sleep, Temperature-controlled Laminar Airflow
in
Respiratory Medicine
volume
147
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:85059543085
  • pmid:30704694
ISSN
0954-6111
DOI
10.1016/j.rmed.2018.12.006
language
English
LU publication?
yes
id
cba90c86-7ccd-43d0-a0e0-8d85bac655db
date added to LUP
2019-01-17 14:27:38
date last changed
2024-02-14 15:24:19
@article{cba90c86-7ccd-43d0-a0e0-8d85bac655db,
  abstract     = {{<p>Background: Allergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA; Airsonett<sup>®</sup>) has been shown to provide significant reduction of exposure to allergens in the breathing zone, leading to long-term reduction in airway inflammation and improvement in quality of life. Allergic asthma patients uncontrolled on GINA step 4 were found to benefit the most. A frequently asked question from clinicians and funders is related to time to onset (TTO) of improvements for patients using TLA. Methods: Asthma Quality of Life Questionnaire (AQLQ) scores were collected in a previous study. TTO of improvements in Quality of Life was analysed for difference (TLA-placebo) in Area-under-Curve using backwards deletion from 12, 9, 6, 3 down to 1 month for the AQLQ total score, the four individual domains and specifically the sleep question. Results: Patients with uncontrolled asthma on GINA step 4 (n = 87)) reported a statistically significant and clinically relevant (≥0.5 point) improvement in total AQLQ score (0.57; p = 0.009) after 3 months treatment for TLA over placebo. The shortest TTO was within 1 month for the environmental domain (0.68; p = 0.016) and the sleep question (0.771; p = 0.037). TTO for the emotional and symptom domains was 3 months (0.66; p = 0.020 and 0.64; p = 0.014 respectively) and for the activity domain 6 months (0.47; p = 0.036). Conclusion: Nocturnal avoidance of allergens using TLA provided a statistically significant and clinically relevant improvement in total AQLQ score within 3 months in patients in the GINA 4 + ACT&lt;18 group. Questions related to sleep quality may provide the first signal of response already within a month after commencing treatment.</p>}},
  author       = {{Bjermer, L. and Eriksson, G. and Radner, F. and Peterson, Stefan and Warner, J. O.}},
  issn         = {{0954-6111}},
  keywords     = {{Allergen avoidance; AQLQ; Quality of Life; Severe allergic asthma; Sleep; Temperature-controlled Laminar Airflow}},
  language     = {{eng}},
  month        = {{02}},
  pages        = {{19--25}},
  publisher    = {{Elsevier}},
  series       = {{Respiratory Medicine}},
  title        = {{Time to onset of improvements in Quality of Life from Temperature-controlled Laminar Airflow (TLA) in severe allergic asthma}},
  url          = {{http://dx.doi.org/10.1016/j.rmed.2018.12.006}},
  doi          = {{10.1016/j.rmed.2018.12.006}},
  volume       = {{147}},
  year         = {{2019}},
}