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Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data

Swiecicka, Agnieszka ; Lunt, Mark ; Ahern, Tomás ; O'Neill, Terence W. ; Bartfai, György ; Casanueva, Felipe ; Forti, Gianni ; Giwercman, Aleksander LU ; Han, Thang S and Lean, Michael E J , et al. (2017) In Journal of Clinical Endocrinology and Metabolism 102(8). p.2798-2806
Abstract

Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding... (More)

Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding protein 3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEA-S), 25-hydroxyvitamin D (25OHD), and parathyroid hormone (PTH), with changes in frailty status (worsening or improving frailty). Results: The risk of worsening FP and FI decreased with 1 standard deviation higher IGF-1, IGFBP-3, and 25OHD in models adjusted for age, body mass index, center, and baseline frailty [IGF-1: odds ratio (OR) for worsening FP, 0.82 (0.73, 0.93), percentage change in FI, -3.7% (-6.0, -1.5); IGFBP-3: 0.84 (0.75, 0.95), -4.2% (-6.4, -2.0); 25OHD: 0.84 (0.75, 0.95); -4.4%, (-6.7, -2.0)]. Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3. Higher DHEA-S was associated with a lower risk of worsening FP only in men >70 years old [OR, 0.57 (0.35, 0.92)]. PTH was unrelated to change in frailty status. Conclusions: These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.

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publication status
published
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in
Journal of Clinical Endocrinology and Metabolism
volume
102
issue
8
pages
9 pages
publisher
Oxford University Press
external identifiers
  • pmid:28609827
  • wos:000407009500017
  • scopus:85026921744
ISSN
0021-972X
DOI
10.1210/jc.2017-00090
language
English
LU publication?
yes
id
cbafae10-219c-405d-af37-70132b510922
date added to LUP
2017-08-23 15:16:54
date last changed
2024-05-12 19:23:48
@article{cbafae10-219c-405d-af37-70132b510922,
  abstract     = {{<p>Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding protein 3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEA-S), 25-hydroxyvitamin D (25OHD), and parathyroid hormone (PTH), with changes in frailty status (worsening or improving frailty). Results: The risk of worsening FP and FI decreased with 1 standard deviation higher IGF-1, IGFBP-3, and 25OHD in models adjusted for age, body mass index, center, and baseline frailty [IGF-1: odds ratio (OR) for worsening FP, 0.82 (0.73, 0.93), percentage change in FI, -3.7% (-6.0, -1.5); IGFBP-3: 0.84 (0.75, 0.95), -4.2% (-6.4, -2.0); 25OHD: 0.84 (0.75, 0.95); -4.4%, (-6.7, -2.0)]. Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3. Higher DHEA-S was associated with a lower risk of worsening FP only in men &gt;70 years old [OR, 0.57 (0.35, 0.92)]. PTH was unrelated to change in frailty status. Conclusions: These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.</p>}},
  author       = {{Swiecicka, Agnieszka and Lunt, Mark and Ahern, Tomás and O'Neill, Terence W. and Bartfai, György and Casanueva, Felipe and Forti, Gianni and Giwercman, Aleksander and Han, Thang S and Lean, Michael E J and Pendleton, Neil and Punab, Margus and Slowikowska-Hilczer, Jolanta and Vanderschueren, Dirk and Huhtaniemi, Ilpo T. and Wu, Frederick C W and Rutter, Martin K.}},
  issn         = {{0021-972X}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{2798--2806}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Clinical Endocrinology and Metabolism}},
  title        = {{Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data}},
  url          = {{http://dx.doi.org/10.1210/jc.2017-00090}},
  doi          = {{10.1210/jc.2017-00090}},
  volume       = {{102}},
  year         = {{2017}},
}