Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus
(2008) In Diabetes Research and Clinical Practice 81(3). p.338-344- Abstract
Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p =... (More)
Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p = 0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p = 0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p = 0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p = 0.13). Conclusions: Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.
(Less)
- author
- publishing date
- 2008-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apolipoprotein B48, Carotid plaque, Diurnal change, ELISA, Type 2 diabetes mellitus
- in
- Diabetes Research and Clinical Practice
- volume
- 81
- issue
- 3
- pages
- 338 - 344
- publisher
- Elsevier
- external identifiers
-
- scopus:48949084729
- ISSN
- 0168-8227
- DOI
- 10.1016/j.diabres.2008.04.028
- language
- English
- LU publication?
- no
- id
- cbb90e39-665d-4882-922a-cc23c0d660fb
- date added to LUP
- 2017-08-23 20:06:52
- date last changed
- 2022-01-30 22:20:06
@article{cbb90e39-665d-4882-922a-cc23c0d660fb, abstract = {{<p>Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p = 0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p = 0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p = 0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p = 0.13). Conclusions: Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.</p>}}, author = {{Tanimura-Inagaki, Kyoko and Nakajima, Yasushi and Nagao, Mototugu and Ishizaki, Akira and Kano-Wakakuri, Toshiko and Harada, Taro and Okajima, Fumitaka and Sudo, Mariko and Tamura, Hideki and Ishii, Shinya and Sugihara, Hitoshi and Yamashita, Shizuya and Asai, Akira and Oikawa, Shinichi}}, issn = {{0168-8227}}, keywords = {{Apolipoprotein B48; Carotid plaque; Diurnal change; ELISA; Type 2 diabetes mellitus}}, language = {{eng}}, number = {{3}}, pages = {{338--344}}, publisher = {{Elsevier}}, series = {{Diabetes Research and Clinical Practice}}, title = {{Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus}}, url = {{http://dx.doi.org/10.1016/j.diabres.2008.04.028}}, doi = {{10.1016/j.diabres.2008.04.028}}, volume = {{81}}, year = {{2008}}, }