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Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus

Tanimura-Inagaki, Kyoko; Nakajima, Yasushi; Nagao, Mototugu LU ; Ishizaki, Akira; Kano-Wakakuri, Toshiko; Harada, Taro; Okajima, Fumitaka; Sudo, Mariko; Tamura, Hideki and Ishii, Shinya, et al. (2008) In Diabetes Research and Clinical Practice 81(3). p.338-344
Abstract

Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p =... (More)

Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p = 0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p = 0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p = 0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p = 0.13). Conclusions: Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.

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type
Contribution to journal
publication status
published
subject
keywords
Apolipoprotein B48, Carotid plaque, Diurnal change, ELISA, Type 2 diabetes mellitus
in
Diabetes Research and Clinical Practice
volume
81
issue
3
pages
338 - 344
publisher
Elsevier
external identifiers
  • scopus:48949084729
ISSN
0168-8227
DOI
10.1016/j.diabres.2008.04.028
language
English
LU publication?
no
id
cbb90e39-665d-4882-922a-cc23c0d660fb
date added to LUP
2017-08-23 20:06:52
date last changed
2017-08-27 06:46:38
@article{cbb90e39-665d-4882-922a-cc23c0d660fb,
  abstract     = {<p>Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p = 0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p = 0.04) levels. In normal LDL-cholesterol (&lt;140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p = 0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p = 0.13). Conclusions: Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.</p>},
  author       = {Tanimura-Inagaki, Kyoko and Nakajima, Yasushi and Nagao, Mototugu and Ishizaki, Akira and Kano-Wakakuri, Toshiko and Harada, Taro and Okajima, Fumitaka and Sudo, Mariko and Tamura, Hideki and Ishii, Shinya and Sugihara, Hitoshi and Yamashita, Shizuya and Asai, Akira and Oikawa, Shinichi},
  issn         = {0168-8227},
  keyword      = {Apolipoprotein B48,Carotid plaque,Diurnal change,ELISA,Type 2 diabetes mellitus},
  language     = {eng},
  number       = {3},
  pages        = {338--344},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus},
  url          = {http://dx.doi.org/10.1016/j.diabres.2008.04.028},
  volume       = {81},
  year         = {2008},
}