Association of exposure to phenols, pesticides, and phthalates with hepatic steatosis and MASLD in adolescents : the potential role of inflammation and lifestyle factors
Yao, Xiaodie ; Tang, Cai ; Li, Yu ; You, Congwei ; Zhang, Haoyang LU
; Gu, Xiaohong
; Liu, Kerong
and Zhang, Le
(2025)
In Metabolism and Target Organ Damage
5(3).
- Abstract
Aim: Limited evidence exists on the effects of endocrine-disrupting chemical exposure on metabolic dysfunctionassociated steatotic liver disease (MASLD) in adolescents. We aimed to assess the effects of multiple chemicals on the hepatic steatosis index (HSI) and MASLD in adolescents, and to further explore the potential roles of inflammation and lifestyle factors. Methods: Associations between chemical exposures and HSI/MASLD were examined using generalized linear models, restricted cubic spline analysis, weighted quantile sum regression, and Bayesian kernel machine regression. Mediation analysis was conducted to evaluate whether inflammation mediated these relationships. Results: Among 2,163 adolescents (median age 15 years), 490... (More)
Aim: Limited evidence exists on the effects of endocrine-disrupting chemical exposure on metabolic dysfunctionassociated steatotic liver disease (MASLD) in adolescents. We aimed to assess the effects of multiple chemicals on the hepatic steatosis index (HSI) and MASLD in adolescents, and to further explore the potential roles of inflammation and lifestyle factors. Methods: Associations between chemical exposures and HSI/MASLD were examined using generalized linear models, restricted cubic spline analysis, weighted quantile sum regression, and Bayesian kernel machine regression. Mediation analysis was conducted to evaluate whether inflammation mediated these relationships. Results: Among 2,163 adolescents (median age 15 years), 490 (22.7%) were diagnosed with MASLD. Bisphenol A, mono-ethyl phthalate, mono-(carboxyoctyl) phthalate, and mono-benzyl phthalate (MBzP) were significantly associated with HSI or MASLD. Both weighted quantile sum and Bayesian kernel machine regression consistently indicated a positive correlation between chemical mixtures and MASLD, with MBzP and bisphenol A identified as key contributors. Mediation analysis showed that white blood cells partially mediated the associations of MBzP with HSI and MASLD, and of mono-(carboxynonyl) phthalate with MASLD. Sedentary behavior and physical activity further modulated the combined effects of chemical mixtures on MASLD. Conclusion: Exposure to phenols, pesticides, and phthalates was significantly associated with HSI or MASLD, with white blood cells acting as a mediator. Reducing sedentary behavior and increasing physical activity may mitigate the adverse impacts of chemical mixtures on MASLD.
(Less)
- author
- Yao, Xiaodie
; Tang, Cai
; Li, Yu
; You, Congwei
; Zhang, Haoyang
LU
; Gu, Xiaohong
; Liu, Kerong
and Zhang, Le
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- EDCs, HSI, inflammatory markers, lifestyle factors, MALSD
- in
- Metabolism and Target Organ Damage
- volume
- 5
- issue
- 3
- article number
- 45
- publisher
- OAE Publishing Inc.
- external identifiers
-
- scopus:105017911891
- DOI
- 10.20517/mtod.2025.103
- language
- English
- LU publication?
- yes
- id
- cbbbeb8a-a8d4-4e26-b728-e860e37b7674
- date added to LUP
- 2025-12-05 11:29:20
- date last changed
- 2025-12-06 03:46:14
@article{cbbbeb8a-a8d4-4e26-b728-e860e37b7674,
abstract = {{<p>Aim: Limited evidence exists on the effects of endocrine-disrupting chemical exposure on metabolic dysfunctionassociated steatotic liver disease (MASLD) in adolescents. We aimed to assess the effects of multiple chemicals on the hepatic steatosis index (HSI) and MASLD in adolescents, and to further explore the potential roles of inflammation and lifestyle factors. Methods: Associations between chemical exposures and HSI/MASLD were examined using generalized linear models, restricted cubic spline analysis, weighted quantile sum regression, and Bayesian kernel machine regression. Mediation analysis was conducted to evaluate whether inflammation mediated these relationships. Results: Among 2,163 adolescents (median age 15 years), 490 (22.7%) were diagnosed with MASLD. Bisphenol A, mono-ethyl phthalate, mono-(carboxyoctyl) phthalate, and mono-benzyl phthalate (MBzP) were significantly associated with HSI or MASLD. Both weighted quantile sum and Bayesian kernel machine regression consistently indicated a positive correlation between chemical mixtures and MASLD, with MBzP and bisphenol A identified as key contributors. Mediation analysis showed that white blood cells partially mediated the associations of MBzP with HSI and MASLD, and of mono-(carboxynonyl) phthalate with MASLD. Sedentary behavior and physical activity further modulated the combined effects of chemical mixtures on MASLD. Conclusion: Exposure to phenols, pesticides, and phthalates was significantly associated with HSI or MASLD, with white blood cells acting as a mediator. Reducing sedentary behavior and increasing physical activity may mitigate the adverse impacts of chemical mixtures on MASLD.</p>}},
author = {{Yao, Xiaodie and Tang, Cai and Li, Yu and You, Congwei and Zhang, Haoyang and Gu, Xiaohong and Liu, Kerong and Zhang, Le}},
keywords = {{EDCs; HSI; inflammatory markers; lifestyle factors; MALSD}},
language = {{eng}},
number = {{3}},
publisher = {{OAE Publishing Inc.}},
series = {{Metabolism and Target Organ Damage}},
title = {{Association of exposure to phenols, pesticides, and phthalates with hepatic steatosis and MASLD in adolescents : the potential role of inflammation and lifestyle factors}},
url = {{http://dx.doi.org/10.20517/mtod.2025.103}},
doi = {{10.20517/mtod.2025.103}},
volume = {{5}},
year = {{2025}},
}