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Production of nitrogen dioxide in a delivery system for inhalation of nitric oxide : a new equation for calculation

Lindberg, L LU and Rydgren, G (1998) In British Journal of Anaesthesia 80(2). p.213-217
Abstract

We have evaluated the kinetics of nitrogen dioxide production in a system for inhalation of nitric oxide. In addition to a small fraction of contamination of nitrogen dioxide in the nitric oxide stock gas, a considerable part of the total concentration of nitrogen dioxide is formed immediately after mixing of nitric oxide and oxygen. This initial build-up of nitrogen dioxide is followed by a linear, time-dependent increase in the concentration of nitrogen dioxide. An equation describing the concentration of nitrogen dioxide in the delivery system is formulated: [NO2] = kA x [NO] + kB x [NO]2 x [O2] + kC x t x [NO]2 x [O2], where nitrogen dioxide [NO2] and nitric oxide [NO] concentrations are in parts per million (ppm), oxygen... (More)

We have evaluated the kinetics of nitrogen dioxide production in a system for inhalation of nitric oxide. In addition to a small fraction of contamination of nitrogen dioxide in the nitric oxide stock gas, a considerable part of the total concentration of nitrogen dioxide is formed immediately after mixing of nitric oxide and oxygen. This initial build-up of nitrogen dioxide is followed by a linear, time-dependent increase in the concentration of nitrogen dioxide. An equation describing the concentration of nitrogen dioxide in the delivery system is formulated: [NO2] = kA x [NO] + kB x [NO]2 x [O2] + kC x t x [NO]2 x [O2], where nitrogen dioxide [NO2] and nitric oxide [NO] concentrations are in parts per million (ppm), oxygen concentration [O2] is expressed as a percentage and contact time (t) is in seconds. The rate constants are kA = 5.12 x 10(-3), kB = 1.41 x 10(-6) and kC = 0.86 x 10(-6). Calculated nitrogen dioxide values correlated well with measured concentrations. This new finding of an initial build-up of nitrogen dioxide has to be taken into consideration if the conversion of nitric oxide to nitrogen dioxide is to be calculated and in the safety guidelines for the use of nitric oxide.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Administration, Inhalation, Humans, Luminescent Measurements, Models, Chemical, Nitric Oxide, Nitrogen Dioxide, Oxidation-Reduction, Oxygen, Respiration, Artificial, Journal Article
in
British Journal of Anaesthesia
volume
80
issue
2
pages
5 pages
publisher
Macmillan
external identifiers
  • scopus:0031942468
ISSN
0007-0912
DOI
10.1093/bja/80.2.213
language
English
LU publication?
yes
id
cbc9db2e-8187-429f-9223-22d200e1b03f
date added to LUP
2018-04-25 13:58:50
date last changed
2018-11-21 21:39:33
@article{cbc9db2e-8187-429f-9223-22d200e1b03f,
  abstract     = {<p>We have evaluated the kinetics of nitrogen dioxide production in a system for inhalation of nitric oxide. In addition to a small fraction of contamination of nitrogen dioxide in the nitric oxide stock gas, a considerable part of the total concentration of nitrogen dioxide is formed immediately after mixing of nitric oxide and oxygen. This initial build-up of nitrogen dioxide is followed by a linear, time-dependent increase in the concentration of nitrogen dioxide. An equation describing the concentration of nitrogen dioxide in the delivery system is formulated: [NO2] = kA x [NO] + kB x [NO]2 x [O2] + kC x t x [NO]2 x [O2], where nitrogen dioxide [NO2] and nitric oxide [NO] concentrations are in parts per million (ppm), oxygen concentration [O2] is expressed as a percentage and contact time (t) is in seconds. The rate constants are kA = 5.12 x 10(-3), kB = 1.41 x 10(-6) and kC = 0.86 x 10(-6). Calculated nitrogen dioxide values correlated well with measured concentrations. This new finding of an initial build-up of nitrogen dioxide has to be taken into consideration if the conversion of nitric oxide to nitrogen dioxide is to be calculated and in the safety guidelines for the use of nitric oxide.</p>},
  author       = {Lindberg, L and Rydgren, G},
  issn         = {0007-0912},
  keyword      = {Administration, Inhalation,Humans,Luminescent Measurements,Models, Chemical,Nitric Oxide,Nitrogen Dioxide,Oxidation-Reduction,Oxygen,Respiration, Artificial,Journal Article},
  language     = {eng},
  number       = {2},
  pages        = {213--217},
  publisher    = {Macmillan},
  series       = {British Journal of Anaesthesia},
  title        = {Production of nitrogen dioxide in a delivery system for inhalation of nitric oxide : a new equation for calculation},
  url          = {http://dx.doi.org/10.1093/bja/80.2.213},
  volume       = {80},
  year         = {1998},
}