Preparation and dissolution profiles of the amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel
(2007) In Drying Technology 25(10). p.1759-1767- Abstract
- The selection of pharmaceutical polymorphisms in the final production step is very important in terms of product recovery, properties, and storage. The amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel were prepared using precipitation, spray drying, and colloid formation methods. These methods were found to be highly efficient and convenient, giving high recovery, short processing time, and good stability, as compared with conventional methods such as freeze drying, evaporation, recrystallization, and melting. The polymorphic natures of the resulting paclitaxel samples were confirmed by XRPD, IR, TGA, DSC, and SEM. The dissolution rates of the paclitaxel samples were studied in pharmaceutical solvents, which... (More)
- The selection of pharmaceutical polymorphisms in the final production step is very important in terms of product recovery, properties, and storage. The amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel were prepared using precipitation, spray drying, and colloid formation methods. These methods were found to be highly efficient and convenient, giving high recovery, short processing time, and good stability, as compared with conventional methods such as freeze drying, evaporation, recrystallization, and melting. The polymorphic natures of the resulting paclitaxel samples were confirmed by XRPD, IR, TGA, DSC, and SEM. The dissolution rates of the paclitaxel samples were studied in pharmaceutical solvents, which included cotton seed oil, corn oil, tricaprylin, and tributyrin. For each solvent, all of the amorphous paclitaxel samples showed much higher dissolution rates than the dihydrated crystalline, anhydrous crystalline, and commercial forms, and can be used for clinical applications that demand improvements in drug delivery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/cbf0d262-9ad8-4f85-aa74-f1dd2dd226ab
- author
- Pyo, Sang-Hyun LU ; Cho, Jin-Suk ; Choi, Ho-Joon and Han, Byung-Hee
- publishing date
- 2007-10-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Amorphous paclitaxel, Morphology
- in
- Drying Technology
- volume
- 25
- issue
- 10
- pages
- 1759 - 1767
- publisher
- TAPPI
- external identifiers
-
- scopus:34848847837
- ISSN
- 1532-2300
- DOI
- 10.1080/07373930701593180
- language
- English
- LU publication?
- no
- id
- cbf0d262-9ad8-4f85-aa74-f1dd2dd226ab
- date added to LUP
- 2024-12-28 10:24:27
- date last changed
- 2025-01-08 11:56:56
@article{cbf0d262-9ad8-4f85-aa74-f1dd2dd226ab,
abstract = {{The selection of pharmaceutical polymorphisms in the final production step is very important in terms of product recovery, properties, and storage. The amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel were prepared using precipitation, spray drying, and colloid formation methods. These methods were found to be highly efficient and convenient, giving high recovery, short processing time, and good stability, as compared with conventional methods such as freeze drying, evaporation, recrystallization, and melting. The polymorphic natures of the resulting paclitaxel samples were confirmed by XRPD, IR, TGA, DSC, and SEM. The dissolution rates of the paclitaxel samples were studied in pharmaceutical solvents, which included cotton seed oil, corn oil, tricaprylin, and tributyrin. For each solvent, all of the amorphous paclitaxel samples showed much higher dissolution rates than the dihydrated crystalline, anhydrous crystalline, and commercial forms, and can be used for clinical applications that demand improvements in drug delivery.}},
author = {{Pyo, Sang-Hyun and Cho, Jin-Suk and Choi, Ho-Joon and Han, Byung-Hee}},
issn = {{1532-2300}},
keywords = {{Amorphous paclitaxel; Morphology}},
language = {{eng}},
month = {{10}},
number = {{10}},
pages = {{1759--1767}},
publisher = {{TAPPI}},
series = {{Drying Technology}},
title = {{Preparation and dissolution profiles of the amorphous, dihydrated crystalline, and anhydrous crystalline forms of paclitaxel}},
url = {{http://dx.doi.org/10.1080/07373930701593180}},
doi = {{10.1080/07373930701593180}},
volume = {{25}},
year = {{2007}},
}