Full-field Electroretinography in Age-related Macular Degeneration : can retinal electrophysiology predict the subjective visual outcome of cataract surgery?
(2020) In Acta Ophthalmologica 98(7). p.693-700- Abstract
Purpose: Predicting the visual gain from cataract surgery when the main cause of vision loss is age-related macular degeneration may be difficult and warrants the need for an objective predictor of subjective outcome. Full-field electroretinography is an objective measure of overall retinal function. We therefore wanted to study if full-field electroretinography can predict subjective visual outcome using visual function questionnaire. Methods: Thirty-one patients with age-related macular degeneration operated for bilateral cataract underwent full-field electroretinography preoperatively. Full-field electroretinography was performed according to International Society for the Clinical Electrophysiology of Vision standards using a... (More)
Purpose: Predicting the visual gain from cataract surgery when the main cause of vision loss is age-related macular degeneration may be difficult and warrants the need for an objective predictor of subjective outcome. Full-field electroretinography is an objective measure of overall retinal function. We therefore wanted to study if full-field electroretinography can predict subjective visual outcome using visual function questionnaire. Methods: Thirty-one patients with age-related macular degeneration operated for bilateral cataract underwent full-field electroretinography preoperatively. Full-field electroretinography was performed according to International Society for the Clinical Electrophysiology of Vision standards using a Ganzfeld bowl (RETI-port/scan 21, Roland, Berlin) and Dawson–Trick–Litzkow fibre electrodes. Vision-related quality of life was measured using the National Eye Institute Visual Function Questionnaire-39 before first-eye surgery and 4.12 ± 2.11 months after second-eye surgery. Results: Mean change in composite visual function questionnaire score after cataract surgery was 9.2 ± 11.9. The patients were divided into three groups: visual function questionnaire composite score increase >10 (n = 17); no change (n = 8); and decrease (n = 6). In the dark-adapted full-field electroretinography responses, we found a significant difference between the three groups in the 0.01 b-wave amplitude (p = 0.05), the 10.0 b-wave amplitude (p = 0.04) and a near-significant difference in 3.0 a-wave amplitude (p = 0.09). Other dark-adapted responses (the 3.0 b-wave and 10.0 a-wave) did not show any significant differences between the three groups, and neither did the light-adapted responses. Conclusion: Patients with low dark-adapted responses on full-field electroretinography preoperatively experience a decrease in subjective vision-related quality of life, suggesting that maintained rod function before cataract surgery may be important.
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- author
- Forshaw, Thomas Richard Johansen ; Ahmed, Hassan Javed ; Kjær, Troels Wesenberg ; Andréasson, Sten LU and Sørensen, Torben Lykke
- organization
- publishing date
- 2020-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- age-related macular degeneration, cataract surgery, full-field electroretinography, visual function questionnaire
- in
- Acta Ophthalmologica
- volume
- 98
- issue
- 7
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32275357
- scopus:85083092979
- ISSN
- 1755-375X
- DOI
- 10.1111/aos.14430
- language
- English
- LU publication?
- yes
- id
- cc38caf0-05e7-487c-a57a-46b9f4f80df5
- date added to LUP
- 2020-05-08 15:36:32
- date last changed
- 2024-04-03 06:26:40
@article{cc38caf0-05e7-487c-a57a-46b9f4f80df5,
abstract = {{<p>Purpose: Predicting the visual gain from cataract surgery when the main cause of vision loss is age-related macular degeneration may be difficult and warrants the need for an objective predictor of subjective outcome. Full-field electroretinography is an objective measure of overall retinal function. We therefore wanted to study if full-field electroretinography can predict subjective visual outcome using visual function questionnaire. Methods: Thirty-one patients with age-related macular degeneration operated for bilateral cataract underwent full-field electroretinography preoperatively. Full-field electroretinography was performed according to International Society for the Clinical Electrophysiology of Vision standards using a Ganzfeld bowl (RETI-port/scan 21, Roland, Berlin) and Dawson–Trick–Litzkow fibre electrodes. Vision-related quality of life was measured using the National Eye Institute Visual Function Questionnaire-39 before first-eye surgery and 4.12 ± 2.11 months after second-eye surgery. Results: Mean change in composite visual function questionnaire score after cataract surgery was 9.2 ± 11.9. The patients were divided into three groups: visual function questionnaire composite score increase >10 (n = 17); no change (n = 8); and decrease (n = 6). In the dark-adapted full-field electroretinography responses, we found a significant difference between the three groups in the 0.01 b-wave amplitude (p = 0.05), the 10.0 b-wave amplitude (p = 0.04) and a near-significant difference in 3.0 a-wave amplitude (p = 0.09). Other dark-adapted responses (the 3.0 b-wave and 10.0 a-wave) did not show any significant differences between the three groups, and neither did the light-adapted responses. Conclusion: Patients with low dark-adapted responses on full-field electroretinography preoperatively experience a decrease in subjective vision-related quality of life, suggesting that maintained rod function before cataract surgery may be important.</p>}},
author = {{Forshaw, Thomas Richard Johansen and Ahmed, Hassan Javed and Kjær, Troels Wesenberg and Andréasson, Sten and Sørensen, Torben Lykke}},
issn = {{1755-375X}},
keywords = {{age-related macular degeneration; cataract surgery; full-field electroretinography; visual function questionnaire}},
language = {{eng}},
number = {{7}},
pages = {{693--700}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Ophthalmologica}},
title = {{Full-field Electroretinography in Age-related Macular Degeneration : can retinal electrophysiology predict the subjective visual outcome of cataract surgery?}},
url = {{http://dx.doi.org/10.1111/aos.14430}},
doi = {{10.1111/aos.14430}},
volume = {{98}},
year = {{2020}},
}