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Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Kindberg, Elin ; Akerlind, Britt ; Johnsen, Christina ; Knudsen, Jenny Dahl ; Heltberg, Ole ; Larson, Göran ; Böttiger, Blenda LU and Svensson, Lennart (2007) In Journal of Clinical Microbiology 45(8). p.2-2720
Abstract

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Caliciviridae Infections/epidemiology, Codon, Nonsense, Denmark, Disease Outbreaks, Fucosyltransferases/genetics, Genotype, Humans, Immunity, Innate/genetics
in
Journal of Clinical Microbiology
volume
45
issue
8
pages
3 pages
publisher
American Society for Microbiology
external identifiers
  • pmid:17537929
  • scopus:34548063203
ISSN
0095-1137
DOI
10.1128/JCM.00162-07
language
English
LU publication?
no
id
cc622341-a300-4928-9a00-b569f1dbc970
date added to LUP
2019-05-02 14:23:33
date last changed
2024-04-02 00:47:01
@article{cc622341-a300-4928-9a00-b569f1dbc970,
  abstract     = {{<p>A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.</p>}},
  author       = {{Kindberg, Elin and Akerlind, Britt and Johnsen, Christina and Knudsen, Jenny Dahl and Heltberg, Ole and Larson, Göran and Böttiger, Blenda and Svensson, Lennart}},
  issn         = {{0095-1137}},
  keywords     = {{Caliciviridae Infections/epidemiology; Codon, Nonsense; Denmark; Disease Outbreaks; Fucosyltransferases/genetics; Genotype; Humans; Immunity, Innate/genetics}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{2--2720}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Journal of Clinical Microbiology}},
  title        = {{Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark}},
  url          = {{http://dx.doi.org/10.1128/JCM.00162-07}},
  doi          = {{10.1128/JCM.00162-07}},
  volume       = {{45}},
  year         = {{2007}},
}