Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark
(2007) In Journal of Clinical Microbiology 45(8). p.2-2720- Abstract
A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.
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https://lup.lub.lu.se/record/cc622341-a300-4928-9a00-b569f1dbc970
- author
- Kindberg, Elin ; Akerlind, Britt ; Johnsen, Christina ; Knudsen, Jenny Dahl ; Heltberg, Ole ; Larson, Göran ; Böttiger, Blenda LU and Svensson, Lennart
- publishing date
- 2007-08
- type
- Contribution to journal
- publication status
- published
- keywords
- Caliciviridae Infections/epidemiology, Codon, Nonsense, Denmark, Disease Outbreaks, Fucosyltransferases/genetics, Genotype, Humans, Immunity, Innate/genetics
- in
- Journal of Clinical Microbiology
- volume
- 45
- issue
- 8
- pages
- 3 pages
- publisher
- American Society for Microbiology
- external identifiers
-
- pmid:17537929
- scopus:34548063203
- ISSN
- 0095-1137
- DOI
- 10.1128/JCM.00162-07
- language
- English
- LU publication?
- no
- id
- cc622341-a300-4928-9a00-b569f1dbc970
- date added to LUP
- 2019-05-02 14:23:33
- date last changed
- 2024-04-02 00:47:01
@article{cc622341-a300-4928-9a00-b569f1dbc970, abstract = {{<p>A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.</p>}}, author = {{Kindberg, Elin and Akerlind, Britt and Johnsen, Christina and Knudsen, Jenny Dahl and Heltberg, Ole and Larson, Göran and Böttiger, Blenda and Svensson, Lennart}}, issn = {{0095-1137}}, keywords = {{Caliciviridae Infections/epidemiology; Codon, Nonsense; Denmark; Disease Outbreaks; Fucosyltransferases/genetics; Genotype; Humans; Immunity, Innate/genetics}}, language = {{eng}}, number = {{8}}, pages = {{2--2720}}, publisher = {{American Society for Microbiology}}, series = {{Journal of Clinical Microbiology}}, title = {{Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark}}, url = {{http://dx.doi.org/10.1128/JCM.00162-07}}, doi = {{10.1128/JCM.00162-07}}, volume = {{45}}, year = {{2007}}, }