Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors
Ketabi, Zohreh ; Bartuma, Katarina LU ; Bernstein, Inge ; Malander, Susanne LU
; Gronberg, Henrik
; Bjorck, Erik
; Holck, Susanne
and Nilbert, Mef
LU
(2011)
In Gynecologic Oncology
121(3).
p.462-465
- Abstract
- Objective. Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. Methods. We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. Results. In total, 63 epithelial ovarian cancers developed at mean 48 (range 30-79) years of age with 47% being early stage (FIGO stage I). Histologically, endometrioid (35%) and clear cell (17%) tumors were overrepresented. The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding... (More)
- Objective. Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. Methods. We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. Results. In total, 63 epithelial ovarian cancers developed at mean 48 (range 30-79) years of age with 47% being early stage (FIGO stage I). Histologically, endometrioid (35%) and clear cell (17%) tumors were overrepresented. The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. Conclusion. The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch syndrome typically presents at young age as early-stage, non-serous tumors, which implicates that a family history of colorectal and endometrial cancer should be specifically considered in such cases. (C) 2011 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1985446
- author
- Ketabi, Zohreh
; Bartuma, Katarina
LU
; Bernstein, Inge
; Malander, Susanne
LU
; Gronberg, Henrik
; Bjorck, Erik
; Holck, Susanne
and Nilbert, Mef
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- HNPCC, Ovarian tumor, MMR, Endometrioid cancer, Clear cell cancer
- in
- Gynecologic Oncology
- volume
- 121
- issue
- 3
- pages
- 462 - 465
- publisher
- Academic Press
- external identifiers
-
- wos:000291240700007
- scopus:79957438303
- pmid:21388660
- ISSN
- 1095-6859
- DOI
- 10.1016/j.ygyno.2011.02.010
- language
- English
- LU publication?
- yes
- id
- ccb44078-0c88-44f6-ad13-c597a6417d02 (old id 1985446)
- date added to LUP
- 2016-04-01 11:15:37
- date last changed
- 2022-02-18 01:17:27
@article{ccb44078-0c88-44f6-ad13-c597a6417d02,
abstract = {{Objective. Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. Methods. We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. Results. In total, 63 epithelial ovarian cancers developed at mean 48 (range 30-79) years of age with 47% being early stage (FIGO stage I). Histologically, endometrioid (35%) and clear cell (17%) tumors were overrepresented. The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. Conclusion. The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch syndrome typically presents at young age as early-stage, non-serous tumors, which implicates that a family history of colorectal and endometrial cancer should be specifically considered in such cases. (C) 2011 Elsevier Inc. All rights reserved.}},
author = {{Ketabi, Zohreh and Bartuma, Katarina and Bernstein, Inge and Malander, Susanne and Gronberg, Henrik and Bjorck, Erik and Holck, Susanne and Nilbert, Mef}},
issn = {{1095-6859}},
keywords = {{HNPCC; Ovarian tumor; MMR; Endometrioid cancer; Clear cell cancer}},
language = {{eng}},
number = {{3}},
pages = {{462--465}},
publisher = {{Academic Press}},
series = {{Gynecologic Oncology}},
title = {{Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors}},
url = {{http://dx.doi.org/10.1016/j.ygyno.2011.02.010}},
doi = {{10.1016/j.ygyno.2011.02.010}},
volume = {{121}},
year = {{2011}},
}