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Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Pischon, T; Lahmann, PH; Boeing, H; Tjonneland, A; Halkjaer, J; Overvad, K; Klipstein-Grobusch, K; Linseisen, J; Becker, N and Trichopoulou, A, et al. (2006) In International Journal of Cancer 118(3). p.728-738
Abstract
Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among... (More)
Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among women, an increased risk of RCC was conferred by body weight (relative risk [RR] in highest vs. lowest quintile 2.13; 95% confidence interval [CI] 1.16-3.90; p-trend 0.003), body mass index (BMI) (RR 2.25; 95% CI = 1.14-4.44; p-trend = 0.009), and waist (RR 1.67; 95% CI = 0.94-2.98; p-trend = 0.003) and hip circumference (RR = 2.30; 95% CI = 1.22-4.34; p-trend = 0.01); however, waist and hip circumference were no longer significant after controlling for body weight. Among men, hip circumference (RR = 0.44; 95% CI = 0.20-0.98; p-trend = 0.03) was related significantly to decreased RCC risk only after accounting for body weight. Height was not related significantly to RCC risk. Our findings suggest that obesity is related to increased risk of RCC irrespective of fat distribution among women, whereas low hip circumference is related to increased RCC risk among men. Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases. (c) 2005 Wiley-Liss, Inc. (Less)
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keywords
cohort study, anthropometry, obesity, epidemiology, kidney cancer
in
International Journal of Cancer
volume
118
issue
3
pages
728 - 738
publisher
John Wiley & Sons
external identifiers
  • wos:000234443900028
  • pmid:16094628
  • scopus:30444438015
ISSN
0020-7136
DOI
10.1002/ijc.21398
language
English
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ccc0c515-164c-4037-b176-d8326a4d2c4d (old id 421546)
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2007-10-14 15:17:23
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@article{ccc0c515-164c-4037-b176-d8326a4d2c4d,
  abstract     = {Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among women, an increased risk of RCC was conferred by body weight (relative risk [RR] in highest vs. lowest quintile 2.13; 95% confidence interval [CI] 1.16-3.90; p-trend 0.003), body mass index (BMI) (RR 2.25; 95% CI = 1.14-4.44; p-trend = 0.009), and waist (RR 1.67; 95% CI = 0.94-2.98; p-trend = 0.003) and hip circumference (RR = 2.30; 95% CI = 1.22-4.34; p-trend = 0.01); however, waist and hip circumference were no longer significant after controlling for body weight. Among men, hip circumference (RR = 0.44; 95% CI = 0.20-0.98; p-trend = 0.03) was related significantly to decreased RCC risk only after accounting for body weight. Height was not related significantly to RCC risk. Our findings suggest that obesity is related to increased risk of RCC irrespective of fat distribution among women, whereas low hip circumference is related to increased RCC risk among men. Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases. (c) 2005 Wiley-Liss, Inc.},
  author       = {Pischon, T and Lahmann, PH and Boeing, H and Tjonneland, A and Halkjaer, J and Overvad, K and Klipstein-Grobusch, K and Linseisen, J and Becker, N and Trichopoulou, A and Benetou, V and Trichopoulos, D and Sieri, S and Palli, D and Tumino, R and Vineis, P and Panico, S and Monninkhof, E and Peeters, PHM and Bueno-de-Mesquita, HB and Buchner, FL and Ljungberg, B and Hallmans, G and Berglund, Göran and Gonzalez, CA and Dorronsoro, M and Gurrea, AB and Navarro, C and Martinez, C and Quiros, JR and Roddam, A and Allen, N and Bingham, S and Khaw, KT and Kaaks, R and Norat, T and Slimani, N and Riboli, E},
  issn         = {0020-7136},
  keyword      = {cohort study,anthropometry,obesity,epidemiology,kidney cancer},
  language     = {eng},
  number       = {3},
  pages        = {728--738},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1002/ijc.21398},
  volume       = {118},
  year         = {2006},
}