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Nouvelle cuisine : platelets served with inflammation

Kapur, Rick; Zufferey, Anne; Boilard, Eric and Semple, John W LU (2015) In Journal of Immunology 194(12). p.87-5579
Abstract

Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release... (More)

Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Blood Platelets, CD40 Ligand, Cell-Derived Microparticles, Cytokines, Histocompatibility Antigens Class I, Host-Pathogen Interactions, Humans, Inflammation, Thrombocytopenia, Toll-Like Receptors, Transcriptome, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Journal of Immunology
volume
194
issue
12
pages
9 pages
publisher
American Association of Immunologists
external identifiers
  • scopus:84931362214
ISSN
1550-6606
DOI
10.4049/jimmunol.1500259
language
English
LU publication?
no
id
cd37be25-6966-4012-a602-63c272d4f5df
date added to LUP
2016-09-23 11:58:43
date last changed
2017-07-09 04:53:17
@article{cd37be25-6966-4012-a602-63c272d4f5df,
  abstract     = {<p>Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.</p>},
  author       = {Kapur, Rick and Zufferey, Anne and Boilard, Eric and Semple, John W},
  issn         = {1550-6606},
  keyword      = {Animals,Blood Platelets,CD40 Ligand,Cell-Derived Microparticles,Cytokines,Histocompatibility Antigens Class I,Host-Pathogen Interactions,Humans,Inflammation,Thrombocytopenia,Toll-Like Receptors,Transcriptome,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  month        = {06},
  number       = {12},
  pages        = {87--5579},
  publisher    = {American Association of Immunologists},
  series       = {Journal of Immunology},
  title        = {Nouvelle cuisine : platelets served with inflammation},
  url          = {http://dx.doi.org/10.4049/jimmunol.1500259},
  volume       = {194},
  year         = {2015},
}