Nouvelle cuisine : platelets served with inflammation
(2015) In Journal of Immunology 194(12). p.87-5579- Abstract
Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release... (More)
Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.
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- author
- Kapur, Rick ; Zufferey, Anne ; Boilard, Eric and Semple, John W LU
- publishing date
- 2015-06-15
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Blood Platelets, CD40 Ligand, Cell-Derived Microparticles, Cytokines, Histocompatibility Antigens Class I, Host-Pathogen Interactions, Humans, Inflammation, Thrombocytopenia, Toll-Like Receptors, Transcriptome, Journal Article, Research Support, Non-U.S. Gov't, Review
- in
- Journal of Immunology
- volume
- 194
- issue
- 12
- pages
- 9 pages
- publisher
- American Association of Immunologists
- external identifiers
-
- pmid:26048965
- scopus:84931362214
- ISSN
- 1550-6606
- DOI
- 10.4049/jimmunol.1500259
- language
- English
- LU publication?
- no
- id
- cd37be25-6966-4012-a602-63c272d4f5df
- date added to LUP
- 2016-09-23 11:58:43
- date last changed
- 2024-06-01 16:28:17
@article{cd37be25-6966-4012-a602-63c272d4f5df,
abstract = {{<p>Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.</p>}},
author = {{Kapur, Rick and Zufferey, Anne and Boilard, Eric and Semple, John W}},
issn = {{1550-6606}},
keywords = {{Animals; Blood Platelets; CD40 Ligand; Cell-Derived Microparticles; Cytokines; Histocompatibility Antigens Class I; Host-Pathogen Interactions; Humans; Inflammation; Thrombocytopenia; Toll-Like Receptors; Transcriptome; Journal Article; Research Support, Non-U.S. Gov't; Review}},
language = {{eng}},
month = {{06}},
number = {{12}},
pages = {{87--5579}},
publisher = {{American Association of Immunologists}},
series = {{Journal of Immunology}},
title = {{Nouvelle cuisine : platelets served with inflammation}},
url = {{http://dx.doi.org/10.4049/jimmunol.1500259}},
doi = {{10.4049/jimmunol.1500259}},
volume = {{194}},
year = {{2015}},
}