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Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest

Grand, Johannes ; Kjaergaard, Jesper ; Nielsen, Niklas LU ; Friberg, Hans LU ; Cronberg, Tobias LU ; Bro-Jeppesen, John ; Karsdal, Morten A. ; Nielsen, Henning B. ; Frydland, Martin and Henriksen, Kim , et al. (2019) In Biomarkers 24(6). p.584-591
Abstract

Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Results: Median (quartile 1–quartile 3) tau-A (ng/ml) values were 58 (43–71) versus 51 (43–67), 72 (57–84) versus 71 (59–82) and 76... (More)

Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Results: Median (quartile 1–quartile 3) tau-A (ng/ml) values were 58 (43–71) versus 51 (43–67), 72 (57–84) versus 71 (59–82) and 76 (61–92) versus 75 (64–89) for good versus unfavourable outcome at 24, 48 and 72 h, respectively (pgroup = 0.95). Median tau C (ng/ml) values were 38 (29–50) versus 36 (29–49), 49 (38–58) versus 48 (33–59) and 48 (39–59) versus 48 (36–62) (pgroup = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 h; tau-A: 0.51 and tau-C: 0.51). Conclusions: Serum levels of tau fragments were unable to predict neurological outcome after OHCA.

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publication status
published
subject
keywords
neurological outcome, out-of-hospital cardiac arrest, prognosis, Serum biomarkers, tau fragments
in
Biomarkers
volume
24
issue
6
pages
584 - 591
publisher
Taylor & Francis
external identifiers
  • pmid:31017476
  • scopus:85066632306
ISSN
1354-750X
DOI
10.1080/1354750X.2019.1609580
language
English
LU publication?
yes
id
cd3c8b4d-6687-4bfc-9ba9-42ffe7786793
date added to LUP
2019-06-24 14:24:02
date last changed
2020-07-08 04:57:10
@article{cd3c8b4d-6687-4bfc-9ba9-42ffe7786793,
  abstract     = {<p>Background: Anoxic brain injury is the primary cause of death after resuscitation from out-of-hospital cardiac arrest (OHCA) and prognostication is challenging. The aim of this study was to evaluate the potential of two fragments of tau as serum biomarkers for neurological outcome. Methods: Single-center sub-study of 171 patients included in the Target Temperature Management (TTM) Trial randomly assigned to TTM at 33 °C or TTM at 36 °C for 24 h after OHCA. Fragments (tau-A and tau-C) of the neuronal protein tau were measured in serum 24, 48 and 72 h after OHCA. The primary endpoint was neurological outcome. Results: Median (quartile 1–quartile 3) tau-A (ng/ml) values were 58 (43–71) versus 51 (43–67), 72 (57–84) versus 71 (59–82) and 76 (61–92) versus 75 (64–89) for good versus unfavourable outcome at 24, 48 and 72 h, respectively (p<sub>group</sub> = 0.95). Median tau C (ng/ml) values were 38 (29–50) versus 36 (29–49), 49 (38–58) versus 48 (33–59) and 48 (39–59) versus 48 (36–62) (p<sub>group</sub> = 0.95). Tau-A and tau-C did not predict neurological outcome (area under the receiver-operating curve at 48 h; tau-A: 0.51 and tau-C: 0.51). Conclusions: Serum levels of tau fragments were unable to predict neurological outcome after OHCA.</p>},
  author       = {Grand, Johannes and Kjaergaard, Jesper and Nielsen, Niklas and Friberg, Hans and Cronberg, Tobias and Bro-Jeppesen, John and Karsdal, Morten A. and Nielsen, Henning B. and Frydland, Martin and Henriksen, Kim and Mattsson, Niklas and Zetterberg, Henrik and Hassager, Christian},
  issn         = {1354-750X},
  language     = {eng},
  month        = {05},
  number       = {6},
  pages        = {584--591},
  publisher    = {Taylor & Francis},
  series       = {Biomarkers},
  title        = {Serum tau fragments as predictors of death or poor neurological outcome after out-of-hospital cardiac arrest},
  url          = {http://dx.doi.org/10.1080/1354750X.2019.1609580},
  doi          = {10.1080/1354750X.2019.1609580},
  volume       = {24},
  year         = {2019},
}