Nuclear factor Y is a pervasive regulator of neuronal gene expression
Moreira, Pedro ; Papatheodorou, Paul ; Deng, Shuer ; Gopal, Sandeep LU
; Handley, Ava
; Powell, David R
and Pocock, Roger
(2023)
In Cell Reports
42(12).
p.1-25
- Abstract
Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting transcription factors (TFs), respectively. Here, we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neuron-type-specific and pan-neuronal gene expression. Mapping global NF-Y targets reveals direct binding to the cis-regulatory regions of pan-neuronal genes and terminal selector TFs. We show that NFYA-1 controls pan-neuronal gene expression directly through binding to CCAAT boxes in target gene promoters and indirectly by regulating the... (More)
Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting transcription factors (TFs), respectively. Here, we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neuron-type-specific and pan-neuronal gene expression. Mapping global NF-Y targets reveals direct binding to the cis-regulatory regions of pan-neuronal genes and terminal selector TFs. We show that NFYA-1 controls pan-neuronal gene expression directly through binding to CCAAT boxes in target gene promoters and indirectly by regulating the expression of terminal selector TFs. Further, we find that NFYA-1 regulation of neuronal gene expression is important for neuronal activity and motor function. Thus, our research sheds light on how global neuronal gene expression programs are buffered through direct and indirect regulatory mechanisms.
(Less)
- author
- Moreira, Pedro
; Papatheodorou, Paul
; Deng, Shuer
; Gopal, Sandeep
LU
; Handley, Ava
; Powell, David R
and Pocock, Roger
- publishing date
- 2023-12-12
- type
- Contribution to journal
- publication status
- published
- in
- Cell Reports
- volume
- 42
- issue
- 12
- article number
- 113582
- pages
- 1 - 25
- publisher
- Cell Press
- external identifiers
-
- scopus:85181396374
- pmid:38096055
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2023.113582
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
- id
- cd5988e3-2fcc-42e9-99cc-3f7f78779b0f
- date added to LUP
- 2023-12-16 20:27:34
- date last changed
- 2024-04-19 08:25:53
@article{cd5988e3-2fcc-42e9-99cc-3f7f78779b0f,
abstract = {{<p>Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting transcription factors (TFs), respectively. Here, we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neuron-type-specific and pan-neuronal gene expression. Mapping global NF-Y targets reveals direct binding to the cis-regulatory regions of pan-neuronal genes and terminal selector TFs. We show that NFYA-1 controls pan-neuronal gene expression directly through binding to CCAAT boxes in target gene promoters and indirectly by regulating the expression of terminal selector TFs. Further, we find that NFYA-1 regulation of neuronal gene expression is important for neuronal activity and motor function. Thus, our research sheds light on how global neuronal gene expression programs are buffered through direct and indirect regulatory mechanisms.</p>}},
author = {{Moreira, Pedro and Papatheodorou, Paul and Deng, Shuer and Gopal, Sandeep and Handley, Ava and Powell, David R and Pocock, Roger}},
issn = {{2211-1247}},
language = {{eng}},
month = {{12}},
number = {{12}},
pages = {{1--25}},
publisher = {{Cell Press}},
series = {{Cell Reports}},
title = {{Nuclear factor Y is a pervasive regulator of neuronal gene expression}},
url = {{http://dx.doi.org/10.1016/j.celrep.2023.113582}},
doi = {{10.1016/j.celrep.2023.113582}},
volume = {{42}},
year = {{2023}},
}