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Towards the development of molecularly imprinted artificial receptors for the screening of estrogenic chemicals

Ye, L. LU ; Yu, Y. LU and Mosbach, K. LU (2001) In Analyst 126(6). p.760-765
Abstract

Molecularly imprinted polymers are prepared using various steroid compounds as the templates. The imprinted polymers can selectively re-bind the original print molecules, which leads to versatile potential applications. The feasibility of using these artificial receptors to replace their biological counterparts for preliminary screening of a chemical library is demonstrated. A steroid library composed of 22 closely related compounds is screened with an estrogen specific polymer. The print molecule is identified with accuracy and structural similarities of other members are correlated with normalized retention indices. Molecularly imprinted artificial receptors are envisioned as being useful for screening purposes in drug discovery or... (More)

Molecularly imprinted polymers are prepared using various steroid compounds as the templates. The imprinted polymers can selectively re-bind the original print molecules, which leads to versatile potential applications. The feasibility of using these artificial receptors to replace their biological counterparts for preliminary screening of a chemical library is demonstrated. A steroid library composed of 22 closely related compounds is screened with an estrogen specific polymer. The print molecule is identified with accuracy and structural similarities of other members are correlated with normalized retention indices. Molecularly imprinted artificial receptors are envisioned as being useful for screening purposes in drug discovery or for identifying endocrine-disrupting chemicals.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analyst
volume
126
issue
6
pages
6 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:11445933
  • scopus:0034961766
ISSN
0003-2654
DOI
10.1039/b009048o
language
English
LU publication?
yes
id
cd81572f-2b43-41e8-97f6-8d51fe33d805
date added to LUP
2019-06-18 09:02:18
date last changed
2021-02-17 04:46:42
@article{cd81572f-2b43-41e8-97f6-8d51fe33d805,
  abstract     = {<p>Molecularly imprinted polymers are prepared using various steroid compounds as the templates. The imprinted polymers can selectively re-bind the original print molecules, which leads to versatile potential applications. The feasibility of using these artificial receptors to replace their biological counterparts for preliminary screening of a chemical library is demonstrated. A steroid library composed of 22 closely related compounds is screened with an estrogen specific polymer. The print molecule is identified with accuracy and structural similarities of other members are correlated with normalized retention indices. Molecularly imprinted artificial receptors are envisioned as being useful for screening purposes in drug discovery or for identifying endocrine-disrupting chemicals.</p>},
  author       = {Ye, L. and Yu, Y. and Mosbach, K.},
  issn         = {0003-2654},
  language     = {eng},
  month        = {07},
  number       = {6},
  pages        = {760--765},
  publisher    = {Royal Society of Chemistry},
  series       = {Analyst},
  title        = {Towards the development of molecularly imprinted artificial receptors for the screening of estrogenic chemicals},
  url          = {http://dx.doi.org/10.1039/b009048o},
  doi          = {10.1039/b009048o},
  volume       = {126},
  year         = {2001},
}