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Novel AKT1 mutations associated with cell-cycle abnormalities in gastric carcinoma

Ghatak, Souvik LU ; Lalnunhlimi, Sylvine ; Lalrohlui, Freda ; Pautu, Jeremy L ; Zohmingthanga, John ; Kunnumakkara, Ajaikumar B. and Kumar, Nachimuthu Senthil (2018) In Personalized Medicine 15(2).
Abstract
Aim: The aim of this study is to identify the AKT1 gene mutation driven pathogenicity in gastric cancer for Mizo population. Methods: 50 diffuse-type gastric tumors were analyzed for AKT1 exon 2 and 14 mutations. Cell-cycle aberration was analyzed in the AKT1-mutated samples and the stability of the protein as well as exonic splicing enhancer motifs were examined. Results: The novel mutations, 15553T >A and 25376C >G might affect the exonic splicing enhancers and silencers. Significant decline was observed in the S-phase population in the tumor cells with 15553T >A and 15579G >C mutations suggesting the arrest of G1 phase. Conclusion: The present study is a novel finding of the possible role of AKT1 mutations which might help... (More)
Aim: The aim of this study is to identify the AKT1 gene mutation driven pathogenicity in gastric cancer for Mizo population. Methods: 50 diffuse-type gastric tumors were analyzed for AKT1 exon 2 and 14 mutations. Cell-cycle aberration was analyzed in the AKT1-mutated samples and the stability of the protein as well as exonic splicing enhancer motifs were examined. Results: The novel mutations, 15553T >A and 25376C >G might affect the exonic splicing enhancers and silencers. Significant decline was observed in the S-phase population in the tumor cells with 15553T >A and 15579G >C mutations suggesting the arrest of G1 phase. Conclusion: The present study is a novel finding of the possible role of AKT1 mutations which might help to identify gastric cancer patients. (Less)
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author
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publishing date
type
Contribution to journal
publication status
published
in
Personalized Medicine
volume
15
issue
2
publisher
Future Science
external identifiers
  • scopus:85041951722
ISSN
1744-828X
DOI
10.2217/pme-2017-0053
language
English
LU publication?
no
id
cdc3bfba-f43b-4ecd-8323-e7f2cb6a10bf
date added to LUP
2021-11-09 16:05:36
date last changed
2022-04-19 17:55:29
@article{cdc3bfba-f43b-4ecd-8323-e7f2cb6a10bf,
  abstract     = {{Aim: The aim of this study is to identify the AKT1 gene mutation driven pathogenicity in gastric cancer for Mizo population. Methods: 50 diffuse-type gastric tumors were analyzed for AKT1 exon 2 and 14 mutations. Cell-cycle aberration was analyzed in the AKT1-mutated samples and the stability of the protein as well as exonic splicing enhancer motifs were examined. Results: The novel mutations, 15553T >A and 25376C >G might affect the exonic splicing enhancers and silencers. Significant decline was observed in the S-phase population in the tumor cells with 15553T >A and 15579G >C mutations suggesting the arrest of G1 phase. Conclusion: The present study is a novel finding of the possible role of AKT1 mutations which might help to identify gastric cancer patients.}},
  author       = {{Ghatak, Souvik and Lalnunhlimi, Sylvine and Lalrohlui, Freda and Pautu, Jeremy L and Zohmingthanga, John and Kunnumakkara, Ajaikumar B. and Kumar, Nachimuthu Senthil}},
  issn         = {{1744-828X}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Future Science}},
  series       = {{Personalized Medicine}},
  title        = {{Novel AKT1 mutations associated with cell-cycle abnormalities in gastric carcinoma}},
  url          = {{http://dx.doi.org/10.2217/pme-2017-0053}},
  doi          = {{10.2217/pme-2017-0053}},
  volume       = {{15}},
  year         = {{2018}},
}