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Can patch testing with methylchloroisothiazolinone/methylisothiazolinone be optimized using a new diagnostic mix? – A multicenter study from the Swedish Contact Dermatitis Research Group

Engfeldt, Malin LU ; Isaksson, Marléne LU ; Bråred-Christensson, Johanna ; Hagvall, Lina ; Matura, Mihály ; Ryberg, Kristina LU ; Stenberg, Berndt ; Svedman, Cecilia LU and Bruze, Magnus LU (2020) In Contact Dermatitis 82(5). p.283-289
Abstract

Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods: A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. Results: The share of contact allergy to MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%,... (More)

Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods: A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. Results: The share of contact allergy to MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%, respectively. MCI/MI 0.215% aq. detected significantly more patch-test positive individuals than both MCI/MI 0.02% aq. (P <.001) and MI 0.2% aq. (P <.001), as well as either one of MCI/MI and MI (P <.001). In the patients only reacting to MCI/MI 0.215% aq., 57.7% were recorded as having a dermatitis that was explained or aggravated by exposure to either MCI/MI or MI. Conclusion: The results speak in favor of replacing the preparations MCI/MI 0.02% aq. and MI 0.2% aq. with MCI/MI 0.215% aq. as the screening substance in the Swedish baseline series, which has been implemented in 2020.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, contact sensitization, delayed hypersensitivity, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), mix, patch testing
in
Contact Dermatitis
volume
82
issue
5
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85082040068
  • pmid:32112437
ISSN
0105-1873
DOI
10.1111/cod.13483
language
English
LU publication?
yes
id
cdcf06fe-7137-4766-b841-f3e1777f5502
date added to LUP
2020-04-09 08:37:33
date last changed
2024-04-03 05:25:36
@article{cdcf06fe-7137-4766-b841-f3e1777f5502,
  abstract     = {{<p>Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods: A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. Results: The share of contact allergy to MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%, respectively. MCI/MI 0.215% aq. detected significantly more patch-test positive individuals than both MCI/MI 0.02% aq. (P &lt;.001) and MI 0.2% aq. (P &lt;.001), as well as either one of MCI/MI and MI (P &lt;.001). In the patients only reacting to MCI/MI 0.215% aq., 57.7% were recorded as having a dermatitis that was explained or aggravated by exposure to either MCI/MI or MI. Conclusion: The results speak in favor of replacing the preparations MCI/MI 0.02% aq. and MI 0.2% aq. with MCI/MI 0.215% aq. as the screening substance in the Swedish baseline series, which has been implemented in 2020.</p>}},
  author       = {{Engfeldt, Malin and Isaksson, Marléne and Bråred-Christensson, Johanna and Hagvall, Lina and Matura, Mihály and Ryberg, Kristina and Stenberg, Berndt and Svedman, Cecilia and Bruze, Magnus}},
  issn         = {{0105-1873}},
  keywords     = {{allergic contact dermatitis; contact sensitization; delayed hypersensitivity; methylchloroisothiazolinone/methylisothiazolinone (MCI/MI); mix; patch testing}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{283--289}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Can patch testing with methylchloroisothiazolinone/methylisothiazolinone be optimized using a new diagnostic mix? – A multicenter study from the Swedish Contact Dermatitis Research Group}},
  url          = {{http://dx.doi.org/10.1111/cod.13483}},
  doi          = {{10.1111/cod.13483}},
  volume       = {{82}},
  year         = {{2020}},
}