Can patch testing with methylchloroisothiazolinone/methylisothiazolinone be optimized using a new diagnostic mix? – A multicenter study from the Swedish Contact Dermatitis Research Group
(2020) In Contact Dermatitis 82(5). p.283-289- Abstract
Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods: A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. Results: The share of contact allergy to MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%,... (More)
Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods: A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. Results: The share of contact allergy to MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%, respectively. MCI/MI 0.215% aq. detected significantly more patch-test positive individuals than both MCI/MI 0.02% aq. (P <.001) and MI 0.2% aq. (P <.001), as well as either one of MCI/MI and MI (P <.001). In the patients only reacting to MCI/MI 0.215% aq., 57.7% were recorded as having a dermatitis that was explained or aggravated by exposure to either MCI/MI or MI. Conclusion: The results speak in favor of replacing the preparations MCI/MI 0.02% aq. and MI 0.2% aq. with MCI/MI 0.215% aq. as the screening substance in the Swedish baseline series, which has been implemented in 2020.
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- author
- Engfeldt, Malin LU ; Isaksson, Marléne LU ; Bråred-Christensson, Johanna ; Hagvall, Lina ; Matura, Mihály ; Ryberg, Kristina LU ; Stenberg, Berndt ; Svedman, Cecilia LU and Bruze, Magnus LU
- organization
- publishing date
- 2020-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergic contact dermatitis, contact sensitization, delayed hypersensitivity, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), mix, patch testing
- in
- Contact Dermatitis
- volume
- 82
- issue
- 5
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85082040068
- pmid:32112437
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.13483
- language
- English
- LU publication?
- yes
- id
- cdcf06fe-7137-4766-b841-f3e1777f5502
- date added to LUP
- 2020-04-09 08:37:33
- date last changed
- 2024-09-18 21:48:57
@article{cdcf06fe-7137-4766-b841-f3e1777f5502, abstract = {{<p>Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones. Objectives: To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq. Methods: A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. Results: The share of contact allergy to MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%, respectively. MCI/MI 0.215% aq. detected significantly more patch-test positive individuals than both MCI/MI 0.02% aq. (P <.001) and MI 0.2% aq. (P <.001), as well as either one of MCI/MI and MI (P <.001). In the patients only reacting to MCI/MI 0.215% aq., 57.7% were recorded as having a dermatitis that was explained or aggravated by exposure to either MCI/MI or MI. Conclusion: The results speak in favor of replacing the preparations MCI/MI 0.02% aq. and MI 0.2% aq. with MCI/MI 0.215% aq. as the screening substance in the Swedish baseline series, which has been implemented in 2020.</p>}}, author = {{Engfeldt, Malin and Isaksson, Marléne and Bråred-Christensson, Johanna and Hagvall, Lina and Matura, Mihály and Ryberg, Kristina and Stenberg, Berndt and Svedman, Cecilia and Bruze, Magnus}}, issn = {{0105-1873}}, keywords = {{allergic contact dermatitis; contact sensitization; delayed hypersensitivity; methylchloroisothiazolinone/methylisothiazolinone (MCI/MI); mix; patch testing}}, language = {{eng}}, number = {{5}}, pages = {{283--289}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Can patch testing with methylchloroisothiazolinone/methylisothiazolinone be optimized using a new diagnostic mix? – A multicenter study from the Swedish Contact Dermatitis Research Group}}, url = {{http://dx.doi.org/10.1111/cod.13483}}, doi = {{10.1111/cod.13483}}, volume = {{82}}, year = {{2020}}, }