The Impact of Senescent Cells on Limb Regeneration
Oesterle, Marlene J LU and Leigh, Nicholas D LU
(2024)
In Cellular Reprogramming
26(3).
p.91-92
- Abstract
Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important feature of senescent cells, since the secreted factors impact the surrounding cellular microenvironment. Indeed, senescent cells and their secretome play a crucial role during limb development. However, whether the process of limb regeneration also relies on senescent cells remains unclear. Creation of a novel targeted depletion strategy that can eliminate senescent cells in the regenerating limb has now demonstrated an important role for senescent cells in limb regeneration. This role is linked to... (More)
Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important feature of senescent cells, since the secreted factors impact the surrounding cellular microenvironment. Indeed, senescent cells and their secretome play a crucial role during limb development. However, whether the process of limb regeneration also relies on senescent cells remains unclear. Creation of a novel targeted depletion strategy that can eliminate senescent cells in the regenerating limb has now demonstrated an important role for senescent cells in limb regeneration. This role is linked to senescent cell-derived Wnt signaling. These findings reveal a previously unknown role for senescent cells during limb regeneration through Wnt signaling.
(Less)
- author
- Oesterle, Marlene J
LU
and Leigh, Nicholas D
LU
- organization
- publishing date
- 2024-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cellular Senescence, Regeneration, Extremities/physiology, Animals, Humans, Wnt Signaling Pathway
- in
- Cellular Reprogramming
- volume
- 26
- issue
- 3
- pages
- 91 - 92
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- scopus:85197284418
- pmid:38717852
- ISSN
- 2152-4971
- DOI
- 10.1089/cell.2024.0021
- language
- English
- LU publication?
- yes
- id
- cdd79768-5e6e-4f04-a6b0-ebf39e3bb856
- date added to LUP
- 2024-09-19 09:08:26
- date last changed
- 2025-07-12 08:05:38
@misc{cdd79768-5e6e-4f04-a6b0-ebf39e3bb856,
abstract = {{<p>Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important feature of senescent cells, since the secreted factors impact the surrounding cellular microenvironment. Indeed, senescent cells and their secretome play a crucial role during limb development. However, whether the process of limb regeneration also relies on senescent cells remains unclear. Creation of a novel targeted depletion strategy that can eliminate senescent cells in the regenerating limb has now demonstrated an important role for senescent cells in limb regeneration. This role is linked to senescent cell-derived Wnt signaling. These findings reveal a previously unknown role for senescent cells during limb regeneration through Wnt signaling.</p>}},
author = {{Oesterle, Marlene J and Leigh, Nicholas D}},
issn = {{2152-4971}},
keywords = {{Cellular Senescence; Regeneration; Extremities/physiology; Animals; Humans; Wnt Signaling Pathway}},
language = {{eng}},
number = {{3}},
pages = {{91--92}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Cellular Reprogramming}},
title = {{The Impact of Senescent Cells on Limb Regeneration}},
url = {{http://dx.doi.org/10.1089/cell.2024.0021}},
doi = {{10.1089/cell.2024.0021}},
volume = {{26}},
year = {{2024}},
}