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Physical Activity and Long-Term Risk of Breast Cancer, Associations with Time in Life and Body Composition in the Prospective Malmö Diet and Cancer Study

Boraka, Öykü LU ; Klintman, Marie LU and Rosendahl, Ann H. LU (2022) In Cancers 14(8).
Abstract

Being physically active as part of everyday life reduces breast cancer risk. Less is known whether the benefits of an active lifestyle differ depending on the timing of physical activity in life or anthropometric characteristics. The aim of this study was to bring further insights to the association of physical activity in relation to menopausal status and body composition with breast cancer risk by making use of a prospective Swedish cohort (Malmö Diet and Cancer Study) with long-term follow-up. Physical activity information of 15,983 participants for the past 12 months prior to study entry was assessed according to metabolic equivalent task (MET)-hours/week to integrate duration and intensity of reported activities. During 23.2 years... (More)

Being physically active as part of everyday life reduces breast cancer risk. Less is known whether the benefits of an active lifestyle differ depending on the timing of physical activity in life or anthropometric characteristics. The aim of this study was to bring further insights to the association of physical activity in relation to menopausal status and body composition with breast cancer risk by making use of a prospective Swedish cohort (Malmö Diet and Cancer Study) with long-term follow-up. Physical activity information of 15,983 participants for the past 12 months prior to study entry was assessed according to metabolic equivalent task (MET)-hours/week to integrate duration and intensity of reported activities. During 23.2 years median follow-up, 1302 invasive breast cancers occurred. Women reporting a high physical activity at study baseline, corresponding to >1 h daily walking/week (≥28.5 MET-h/week), had a 23% lower long-term breast cancer risk (HRadj = 0.77, 95% CI 0.66–0.90) than those reporting low physical activity, being most pronounced among perimenopausal and postmenopausal women, and women with waist circumference, body fat percentage, or BMI in the upper-normal and overweight range. For premenopausal women or women having obesity or the largest body composition, high physical activity alone did not modify the breast cancer risk, suggesting additional preventive measures indicated in these groups to reduce the long-term risk of breast cancer.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
body composition, breast cancer, menopausal status, physical activity
in
Cancers
volume
14
issue
8
article number
1960
publisher
MDPI AG
external identifiers
  • pmid:35454864
  • scopus:85128180038
ISSN
2072-6694
DOI
10.3390/cancers14081960
language
English
LU publication?
yes
id
ce0f7a7e-893a-4c1c-8548-9588918356cd
date added to LUP
2022-07-01 12:00:27
date last changed
2024-06-27 19:15:18
@article{ce0f7a7e-893a-4c1c-8548-9588918356cd,
  abstract     = {{<p>Being physically active as part of everyday life reduces breast cancer risk. Less is known whether the benefits of an active lifestyle differ depending on the timing of physical activity in life or anthropometric characteristics. The aim of this study was to bring further insights to the association of physical activity in relation to menopausal status and body composition with breast cancer risk by making use of a prospective Swedish cohort (Malmö Diet and Cancer Study) with long-term follow-up. Physical activity information of 15,983 participants for the past 12 months prior to study entry was assessed according to metabolic equivalent task (MET)-hours/week to integrate duration and intensity of reported activities. During 23.2 years median follow-up, 1302 invasive breast cancers occurred. Women reporting a high physical activity at study baseline, corresponding to &gt;1 h daily walking/week (≥28.5 MET-h/week), had a 23% lower long-term breast cancer risk (HR<sub>adj</sub> = 0.77, 95% CI 0.66–0.90) than those reporting low physical activity, being most pronounced among perimenopausal and postmenopausal women, and women with waist circumference, body fat percentage, or BMI in the upper-normal and overweight range. For premenopausal women or women having obesity or the largest body composition, high physical activity alone did not modify the breast cancer risk, suggesting additional preventive measures indicated in these groups to reduce the long-term risk of breast cancer.</p>}},
  author       = {{Boraka, Öykü and Klintman, Marie and Rosendahl, Ann H.}},
  issn         = {{2072-6694}},
  keywords     = {{body composition; breast cancer; menopausal status; physical activity}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{8}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Physical Activity and Long-Term Risk of Breast Cancer, Associations with Time in Life and Body Composition in the Prospective Malmö Diet and Cancer Study}},
  url          = {{http://dx.doi.org/10.3390/cancers14081960}},
  doi          = {{10.3390/cancers14081960}},
  volume       = {{14}},
  year         = {{2022}},
}