Shrunken pore syndrome in heart transplantation : a pore ready to close?
Herou, Erik LU
; Mörtsell, Emilie
LU
; Grubb, Anders
LU
; Nozohoor, Shahab
LU
; Zindovic, Igor
LU
; Ederoth, Per
LU
; Dardashti, Alain
LU
and Bjursten, Henrik
LU
(2025)
In Scandinavian Cardiovascular Journal
59(1).
- Abstract
Background: A newly discovered renal syndrome, shrunken pore syndrome (SPS), has been shown to increase mortality regardless of renal function. SPS is defined as an estimated glomerular filtration rate (eGFR) of cystatin C ≤ 60% than eGFRcreatinine. We set out to study SPS in relation to the survival of heart transplantation patients with a follow-up of up to 12 years. Methods. This was a single-center cohort study including 253 consecutive patients undergoing heart transplantation. The prevalence of SPS at different time points post-transplantation and its effect on survival was evaluated using Kaplan–Meier’s analysis and multivariable Cox proportional hazards regression. Results. The prevalence of SPS was 7.5% the day after... (More)
Background: A newly discovered renal syndrome, shrunken pore syndrome (SPS), has been shown to increase mortality regardless of renal function. SPS is defined as an estimated glomerular filtration rate (eGFR) of cystatin C ≤ 60% than eGFRcreatinine. We set out to study SPS in relation to the survival of heart transplantation patients with a follow-up of up to 12 years. Methods. This was a single-center cohort study including 253 consecutive patients undergoing heart transplantation. The prevalence of SPS at different time points post-transplantation and its effect on survival was evaluated using Kaplan–Meier’s analysis and multivariable Cox proportional hazards regression. Results. The prevalence of SPS was 7.5% the day after transplantation (D1), which rose to 71% week 4 after surgery. There was no difference in survival for patients with SPS D1 compared to patients without SPS D1. Patients with SPS 4 weeks compared to patients without SPS 4 weeks after transplantation showed a 5- and 10-year survival of 73% vs. 93% (p = .02) and 63% vs. 90% (p = .005), respectively. SPS developed during the postoperative period was also found to be an independent predictor of mortality (HR 4.65; 95% CI 1.36–15.8). Discussion. SPS that developed in the postoperative course after heart transplantation was found to be an independent predictor of mortality with a severe negative impact on 5- and 10-year survival.
(Less)
- author
- Herou, Erik
LU
; Mörtsell, Emilie
LU
; Grubb, Anders
LU
; Nozohoor, Shahab
LU
; Zindovic, Igor
LU
; Ederoth, Per
LU
; Dardashti, Alain
LU
and Bjursten, Henrik
LU
- organization
-
- Minimal invasive cardiac surgery in valvular heart disease (research group)
- Bleeding disorders and acute typ-A dissection (research group)
- Thoracic Surgery
- Anesthesiology and Intensive Care
- Cystatin C, renal disease, amyloidosis and antibiotics (research group)
- Neurological injury in acute type A aortic dissection (research group)
- Heparin bindning protein in cardiothoracic surgery (research group)
- Cardiothoracic anesthesia and intensive care (research group)
- Less invasive cardiac surgery (research group)
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- creatinine, cystatin C, glomerular filtration rate, Heart transplantation, renal failure, shrunken pore syndrome
- in
- Scandinavian Cardiovascular Journal
- volume
- 59
- issue
- 1
- article number
- 2481173
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:105000696040
- pmid:40094887
- ISSN
- 1401-7431
- DOI
- 10.1080/14017431.2025.2481173
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
- id
- ce1a6e92-c282-40dc-b2b0-9ca1084e6a8b
- date added to LUP
- 2025-06-05 09:55:38
- date last changed
- 2025-07-03 12:50:00
@article{ce1a6e92-c282-40dc-b2b0-9ca1084e6a8b,
abstract = {{<p>Background: A newly discovered renal syndrome, shrunken pore syndrome (SPS), has been shown to increase mortality regardless of renal function. SPS is defined as an estimated glomerular filtration rate (eGFR) of cystatin C ≤ 60% than eGFR<sub>creatinine</sub>. We set out to study SPS in relation to the survival of heart transplantation patients with a follow-up of up to 12 years. Methods. This was a single-center cohort study including 253 consecutive patients undergoing heart transplantation. The prevalence of SPS at different time points post-transplantation and its effect on survival was evaluated using Kaplan–Meier’s analysis and multivariable Cox proportional hazards regression. Results. The prevalence of SPS was 7.5% the day after transplantation (D1), which rose to 71% week 4 after surgery. There was no difference in survival for patients with SPS D1 compared to patients without SPS D1. Patients with SPS 4 weeks compared to patients without SPS 4 weeks after transplantation showed a 5- and 10-year survival of 73% vs. 93% (p = .02) and 63% vs. 90% (p = .005), respectively. SPS developed during the postoperative period was also found to be an independent predictor of mortality (HR 4.65; 95% CI 1.36–15.8). Discussion. SPS that developed in the postoperative course after heart transplantation was found to be an independent predictor of mortality with a severe negative impact on 5- and 10-year survival.</p>}},
author = {{Herou, Erik and Mörtsell, Emilie and Grubb, Anders and Nozohoor, Shahab and Zindovic, Igor and Ederoth, Per and Dardashti, Alain and Bjursten, Henrik}},
issn = {{1401-7431}},
keywords = {{creatinine; cystatin C; glomerular filtration rate; Heart transplantation; renal failure; shrunken pore syndrome}},
language = {{eng}},
number = {{1}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Cardiovascular Journal}},
title = {{Shrunken pore syndrome in heart transplantation : a pore ready to close?}},
url = {{http://dx.doi.org/10.1080/14017431.2025.2481173}},
doi = {{10.1080/14017431.2025.2481173}},
volume = {{59}},
year = {{2025}},
}