Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.
Sommandas, Vinod ; Rutledge, Elizabeth A. ; Van Yserloo, Brian ; Fuller, Jessica ; Lernmark, Åke LU
and Drexhage, Hemmo A.
(2005)
In Journal of Autoimmunity
25(1).
p.1-12
- Abstract
- BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells (DC) from bone-marrow precursors, we tested the hypothesis that F344 rats congenic for a BB-DP chromosome 4 region (42.5-93.6Mb; including the lyp gene, but also iddm4) display an in vitro DC differentiation different from normal F344 rats. Here we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor... (More)
- BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells (DC) from bone-marrow precursors, we tested the hypothesis that F344 rats congenic for a BB-DP chromosome 4 region (42.5-93.6Mb; including the lyp gene, but also iddm4) display an in vitro DC differentiation different from normal F344 rats. Here we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor apoptosis, a low MHC class II expression, a reduced IL-10 production and a reduced T cell stimulatory capacity of DC. From our previous report on DC differentiation defects in BB rats (only differing in iddm2) and the present report, we deduce that the abnorma (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1129980
- author
- Sommandas, Vinod
; Rutledge, Elizabeth A.
; Van Yserloo, Brian
; Fuller, Jessica
; Lernmark, Åke
LU
and Drexhage, Hemmo A.
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- BB rat, Diabetes, Dendritic cells, lyp gene
- in
- Journal of Autoimmunity
- volume
- 25
- issue
- 1
- pages
- 1 - 12
- publisher
- Elsevier
- external identifiers
-
- scopus:22444444425
- pmid:16023326
- ISSN
- 0896-8411
- DOI
- 10.1016/j.jaut.2005.05.002
- language
- English
- LU publication?
- no
- id
- ce2a493c-5209-4e01-ae0a-05f8f6415bb9 (old id 1129980)
- date added to LUP
- 2016-04-01 12:36:02
- date last changed
- 2022-01-27 07:17:25
@article{ce2a493c-5209-4e01-ae0a-05f8f6415bb9,
abstract = {{BB-Diabetes Prone (BB-DP) rats, a model for endocrine autoimmune diseases, are severely lymphopenic, especially lacking ART2+ regulatory T cells. BB-Diabetes Resistant (DR) rats are not lymphopenic and do not develop autoimmunity. BB-DP and BB-DR rats only differ at the lymphopenia (lyp) gene (iddm2) on chromosome 4. Since BB-DP rats also show aberrancies in the differentiation of dendritic cells (DC) from bone-marrow precursors, we tested the hypothesis that F344 rats congenic for a BB-DP chromosome 4 region (42.5-93.6Mb; including the lyp gene, but also iddm4) display an in vitro DC differentiation different from normal F344 rats. Here we show that the 42.5-93.6Mb BB-DP chromosome 4 region is linked to an increased DC precursor apoptosis, a low MHC class II expression, a reduced IL-10 production and a reduced T cell stimulatory capacity of DC. From our previous report on DC differentiation defects in BB rats (only differing in iddm2) and the present report, we deduce that the abnorma}},
author = {{Sommandas, Vinod and Rutledge, Elizabeth A. and Van Yserloo, Brian and Fuller, Jessica and Lernmark, Åke and Drexhage, Hemmo A.}},
issn = {{0896-8411}},
keywords = {{BB rat; Diabetes; Dendritic cells; lyp gene}},
language = {{eng}},
number = {{1}},
pages = {{1--12}},
publisher = {{Elsevier}},
series = {{Journal of Autoimmunity}},
title = {{Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.}},
url = {{http://dx.doi.org/10.1016/j.jaut.2005.05.002}},
doi = {{10.1016/j.jaut.2005.05.002}},
volume = {{25}},
year = {{2005}},
}