The effects of enalapril on the natriuretic response evoked by an oral sodium load in sodium deprived normotensive and hypertensive rats
(1997) In Acta Physiologica Scandinavica 160(2). p.157-164- Abstract
Previous studies have shown that an oral sodium load during sodium deprivation is excreted faster than an intravenous load. We wanted to study whether the renin-angiotensin-aldosterone system might be associated with this phenomenon and therefore the influence of the angiotensin converting enzyme (ACE) inhibitor enalapril was investigated. The experiments were performed on four strains of rat: spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY) rats, inbred hypertension-prone (SS/Jr) and hypertension-resistant (SR/Jr) Dahl rats. In SHR and WKY rats pretreated with enatapril it was observed that an intravenous sodium load induced a renal sodium excretion which was between two and five times larger than that seen after an oral load.... (More)
Previous studies have shown that an oral sodium load during sodium deprivation is excreted faster than an intravenous load. We wanted to study whether the renin-angiotensin-aldosterone system might be associated with this phenomenon and therefore the influence of the angiotensin converting enzyme (ACE) inhibitor enalapril was investigated. The experiments were performed on four strains of rat: spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY) rats, inbred hypertension-prone (SS/Jr) and hypertension-resistant (SR/Jr) Dahl rats. In SHR and WKY rats pretreated with enatapril it was observed that an intravenous sodium load induced a renal sodium excretion which was between two and five times larger than that seen after an oral load. In SR/Jr and SS/Jr rats the sodium excretion was the same regardless of the route of administration. In SS/Jr rats sodium excretion increased three- to fourfold upon sodium repletion, whereas no significant increase was observed in SR/Jr rats. Thus, the present results indicate that an intact renin-angiotensin system is necessary for the interplay between the gastrointestinal tract and kidney.
(Less)
- author
- Mu, J. Y. ; Johansson, Martin LU and Lundgren, O
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- keywords
- ACE-inhibitor, Enalapril, Gastrointestinal tract, Kidney, Sodium chloride
- in
- Acta Physiologica Scandinavica
- volume
- 160
- issue
- 2
- pages
- 157 - 164
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9208042
- scopus:0030974647
- ISSN
- 0001-6772
- language
- English
- LU publication?
- no
- id
- ce450da0-ff3b-48f2-a725-6305b9d10c20
- date added to LUP
- 2017-04-10 17:00:14
- date last changed
- 2024-01-13 18:34:17
@article{ce450da0-ff3b-48f2-a725-6305b9d10c20,
abstract = {{<p>Previous studies have shown that an oral sodium load during sodium deprivation is excreted faster than an intravenous load. We wanted to study whether the renin-angiotensin-aldosterone system might be associated with this phenomenon and therefore the influence of the angiotensin converting enzyme (ACE) inhibitor enalapril was investigated. The experiments were performed on four strains of rat: spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY) rats, inbred hypertension-prone (SS/Jr) and hypertension-resistant (SR/Jr) Dahl rats. In SHR and WKY rats pretreated with enatapril it was observed that an intravenous sodium load induced a renal sodium excretion which was between two and five times larger than that seen after an oral load. In SR/Jr and SS/Jr rats the sodium excretion was the same regardless of the route of administration. In SS/Jr rats sodium excretion increased three- to fourfold upon sodium repletion, whereas no significant increase was observed in SR/Jr rats. Thus, the present results indicate that an intact renin-angiotensin system is necessary for the interplay between the gastrointestinal tract and kidney.</p>}},
author = {{Mu, J. Y. and Johansson, Martin and Lundgren, O}},
issn = {{0001-6772}},
keywords = {{ACE-inhibitor; Enalapril; Gastrointestinal tract; Kidney; Sodium chloride}},
language = {{eng}},
number = {{2}},
pages = {{157--164}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Physiologica Scandinavica}},
title = {{The effects of enalapril on the natriuretic response evoked by an oral sodium load in sodium deprived normotensive and hypertensive rats}},
volume = {{160}},
year = {{1997}},
}