Advanced

Tumors of the skin

Mertens, Fredrik LU ; Mitelman, Felix LU and Heim, Sverre LU (2015) In Cancer Cytogenetics p.555-565
Abstract

Skin cancer is the most common malignancy in humans. Clonal chromosome abnormalities have been reported in approximately 100 basal cell epitheliomas (BCC). In contrast to BCC, which has no recognized precursor lesion, squamous cell carcinoma (SCC) of the skin is known to develop through histologic stages, the most important of which are actinic keratosis (squamous cell dysplasia) and carcinoma in situ (severe dysplasia). A wide range of clinically and pathologically different benign and malignant melanocytic tumors are recognized. Appendageal tumors are subdivided into more than 30 benign and malignant subtypes showing apocrine and eccrine differentiation or follicular and sebaceous differentiation. Merkel cell carcinomas have... (More)

Skin cancer is the most common malignancy in humans. Clonal chromosome abnormalities have been reported in approximately 100 basal cell epitheliomas (BCC). In contrast to BCC, which has no recognized precursor lesion, squamous cell carcinoma (SCC) of the skin is known to develop through histologic stages, the most important of which are actinic keratosis (squamous cell dysplasia) and carcinoma in situ (severe dysplasia). A wide range of clinically and pathologically different benign and malignant melanocytic tumors are recognized. Appendageal tumors are subdivided into more than 30 benign and malignant subtypes showing apocrine and eccrine differentiation or follicular and sebaceous differentiation. Merkel cell carcinomas have near-diploid karyotypes, often showing rearrangements of chromosome 1. Dermal cylindromas may show similar genetic features to adenoid cystic carcinomas with the occurrence of a t (6; 9) (q22-23; p23-24) leading to a MYB-NFIB fusion gene.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Actinic keratosis, Appendageal tumors, Basal cell epitheliomas, Carcinoma in situ, Malignant melanocytic tumors, Merkel cell carcinomas, Skin cancer, Squamous cell carcinoma
in
Cancer Cytogenetics
editor
Heim, Sverre; Mitelman, Felix ; and
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85015974851
ISBN
9781118795538
9781118795569
DOI
10.1002/9781118795569.ch22
language
English
LU publication?
yes
id
ce553a17-517a-4eff-9342-e7cf517745a0
date added to LUP
2017-04-20 11:33:38
date last changed
2017-04-20 11:33:38
@inbook{ce553a17-517a-4eff-9342-e7cf517745a0,
  abstract     = {<p>Skin cancer is the most common malignancy in humans. Clonal chromosome abnormalities have been reported in approximately 100 basal cell epitheliomas (BCC). In contrast to BCC, which has no recognized precursor lesion, squamous cell carcinoma (SCC) of the skin is known to develop through histologic stages, the most important of which are actinic keratosis (squamous cell dysplasia) and carcinoma in situ (severe dysplasia). A wide range of clinically and pathologically different benign and malignant melanocytic tumors are recognized. Appendageal tumors are subdivided into more than 30 benign and malignant subtypes showing apocrine and eccrine differentiation or follicular and sebaceous differentiation. Merkel cell carcinomas have near-diploid karyotypes, often showing rearrangements of chromosome 1. Dermal cylindromas may show similar genetic features to adenoid cystic carcinomas with the occurrence of a t (6; 9) (q22-23; p23-24) leading to a MYB-NFIB fusion gene.</p>},
  author       = {Mertens, Fredrik and Mitelman, Felix and Heim, Sverre},
  editor       = {Heim, Sverre and Mitelman, Felix },
  isbn         = {9781118795538},
  keyword      = {Actinic keratosis,Appendageal tumors,Basal cell epitheliomas,Carcinoma in situ,Malignant melanocytic tumors,Merkel cell carcinomas,Skin cancer,Squamous cell carcinoma},
  language     = {eng},
  pages        = {555--565},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Cytogenetics},
  title        = {Tumors of the skin},
  url          = {http://dx.doi.org/10.1002/9781118795569.ch22},
  year         = {2015},
}