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Mixed Phenotype/Lineage Leukemia : Has Anything Changed for 2021 on Diagnosis, Classification, and Treatment?

Béné, Marie C. and Porwit, Anna LU (2022) In Current Oncology Reports 24(8). p.1015-1022
Abstract

Purpose of Review: Recent advances in the small field of the rare mixed phenotype acute leukemias (MPAL) are presented focusing on a better understanding of their pathophysiology and search for better therapeutic approaches. Recent Findings: Three aspects of respective classification, therapy, and immunophenotype of MPAL are reviewed. New proposals have been made to segregate MPAL subtypes based on their genomic landscape. In parallel, it was found that a large array of therapeutic approaches has been tested in the past few years with increasingly good results. Finally, we explored the use of unsupervised flow cytometry analysis to dissect subtle variations in markers expression to better characterize the variegating aspect of MPALs.... (More)

Purpose of Review: Recent advances in the small field of the rare mixed phenotype acute leukemias (MPAL) are presented focusing on a better understanding of their pathophysiology and search for better therapeutic approaches. Recent Findings: Three aspects of respective classification, therapy, and immunophenotype of MPAL are reviewed. New proposals have been made to segregate MPAL subtypes based on their genomic landscape. In parallel, it was found that a large array of therapeutic approaches has been tested in the past few years with increasingly good results. Finally, we explored the use of unsupervised flow cytometry analysis to dissect subtle variations in markers expression to better characterize the variegating aspect of MPALs. Summary: Genomic and immunophenotypic aspects more clearly link MPAL subtypes with bona fide acute myeloblastic of lymphoblastic leukemias. This is likely to impact therapeutic strategies, towards a better management and outcome.

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type
Contribution to journal
publication status
published
subject
keywords
Acute leukemia, Allogeneic hematopoietic stem cell transplantation, Ambiguous lineage, Fusion genes, Genomics, Immunophenotyping, Immunotherapy, Morphology, MPAL, Mutations, Translocations, Tyrosine kinase inhibitors, Unsupervised flow cytometry clustering
in
Current Oncology Reports
volume
24
issue
8
pages
1015 - 1022
publisher
Current Science, Inc.
external identifiers
  • pmid:35380407
  • scopus:85127589667
ISSN
1523-3790
DOI
10.1007/s11912-022-01252-w
language
English
LU publication?
yes
id
ce59a702-db1f-45bd-a678-74543389c62f
date added to LUP
2022-05-04 12:11:43
date last changed
2025-03-07 14:28:16
@article{ce59a702-db1f-45bd-a678-74543389c62f,
  abstract     = {{<p>Purpose of Review: Recent advances in the small field of the rare mixed phenotype acute leukemias (MPAL) are presented focusing on a better understanding of their pathophysiology and search for better therapeutic approaches. Recent Findings: Three aspects of respective classification, therapy, and immunophenotype of MPAL are reviewed. New proposals have been made to segregate MPAL subtypes based on their genomic landscape. In parallel, it was found that a large array of therapeutic approaches has been tested in the past few years with increasingly good results. Finally, we explored the use of unsupervised flow cytometry analysis to dissect subtle variations in markers expression to better characterize the variegating aspect of MPALs. Summary: Genomic and immunophenotypic aspects more clearly link MPAL subtypes with bona fide acute myeloblastic of lymphoblastic leukemias. This is likely to impact therapeutic strategies, towards a better management and outcome.</p>}},
  author       = {{Béné, Marie C. and Porwit, Anna}},
  issn         = {{1523-3790}},
  keywords     = {{Acute leukemia; Allogeneic hematopoietic stem cell transplantation; Ambiguous lineage; Fusion genes; Genomics; Immunophenotyping; Immunotherapy; Morphology; MPAL; Mutations; Translocations; Tyrosine kinase inhibitors; Unsupervised flow cytometry clustering}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1015--1022}},
  publisher    = {{Current Science, Inc.}},
  series       = {{Current Oncology Reports}},
  title        = {{Mixed Phenotype/Lineage Leukemia : Has Anything Changed for 2021 on Diagnosis, Classification, and Treatment?}},
  url          = {{http://dx.doi.org/10.1007/s11912-022-01252-w}},
  doi          = {{10.1007/s11912-022-01252-w}},
  volume       = {{24}},
  year         = {{2022}},
}