Spontaneous Vesicle Formation in Catanionic Mixtures of Amino Acid-Based Surfactants: Chain Length Symmetry Effects.
(2008) In Langmuir 24(19). p.11009-11017- Abstract
- The use of amino acids for the synthesis of novel surfactants with vesicle-forming properties potentially enhances the biocompatibility levels needed for a viable alternative to conventional lipid vesicles. In this work, the formation and characterization of catanionic vesicles by newly synthesized lysine- and serine-derived surfactants have been investigated by means of phase behavior mapping and PFG-NMR diffusometry and cryo-TEM methods. The lysine-derived surfactants are double-chained anionic molecules bearing a pseudogemini configuration, whereas the serine-derived amphiphile is cationic and single-chained. Vesicles form in the cationic-rich side for narrow mixing ratios of the two amphiphiles. Two pairs of systems were studied: one... (More)
- The use of amino acids for the synthesis of novel surfactants with vesicle-forming properties potentially enhances the biocompatibility levels needed for a viable alternative to conventional lipid vesicles. In this work, the formation and characterization of catanionic vesicles by newly synthesized lysine- and serine-derived surfactants have been investigated by means of phase behavior mapping and PFG-NMR diffusometry and cryo-TEM methods. The lysine-derived surfactants are double-chained anionic molecules bearing a pseudogemini configuration, whereas the serine-derived amphiphile is cationic and single-chained. Vesicles form in the cationic-rich side for narrow mixing ratios of the two amphiphiles. Two pairs of systems were studied: one symmetric with equal chain lengths, 2C 12/C 12, and the other highly asymmetric with 2C 8/C 16 chains, where the serine-based surfactant has the longest chain. Different mechanisms of the vesicle-to-micelle transition were found, depending on symmetry: the 2C 12/C 12 system entails limited micellar growth and intermediate phase separation, whereas the 2C 8/C 16 system shows a continuous transition involving large wormlike micelles. The results are interpreted on the basis of currently available models for the micelle-vesicle transitions and the stabilization of catanionic vesicles (energy of curvature vs mixing entropy). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1222981
- author
- Marques, Eduardo ; de Oliveira Brito, Rodrigo ; Silva, Sandra ; Rodríguez-Borges, J ; Vale, Maria ; Gomes, Paula ; Araújo, Maria and Söderman, Olle LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langmuir
- volume
- 24
- issue
- 19
- pages
- 11009 - 11017
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:18720960
- wos:000259673500073
- scopus:54549114386
- ISSN
- 0743-7463
- DOI
- 10.1021/la801518h
- language
- English
- LU publication?
- yes
- id
- ce66584c-be63-4df7-8fa7-5bd9b3c74aef (old id 1222981)
- date added to LUP
- 2016-04-01 11:40:51
- date last changed
- 2022-04-28 18:27:58
@article{ce66584c-be63-4df7-8fa7-5bd9b3c74aef,
abstract = {{The use of amino acids for the synthesis of novel surfactants with vesicle-forming properties potentially enhances the biocompatibility levels needed for a viable alternative to conventional lipid vesicles. In this work, the formation and characterization of catanionic vesicles by newly synthesized lysine- and serine-derived surfactants have been investigated by means of phase behavior mapping and PFG-NMR diffusometry and cryo-TEM methods. The lysine-derived surfactants are double-chained anionic molecules bearing a pseudogemini configuration, whereas the serine-derived amphiphile is cationic and single-chained. Vesicles form in the cationic-rich side for narrow mixing ratios of the two amphiphiles. Two pairs of systems were studied: one symmetric with equal chain lengths, 2C 12/C 12, and the other highly asymmetric with 2C 8/C 16 chains, where the serine-based surfactant has the longest chain. Different mechanisms of the vesicle-to-micelle transition were found, depending on symmetry: the 2C 12/C 12 system entails limited micellar growth and intermediate phase separation, whereas the 2C 8/C 16 system shows a continuous transition involving large wormlike micelles. The results are interpreted on the basis of currently available models for the micelle-vesicle transitions and the stabilization of catanionic vesicles (energy of curvature vs mixing entropy).}},
author = {{Marques, Eduardo and de Oliveira Brito, Rodrigo and Silva, Sandra and Rodríguez-Borges, J and Vale, Maria and Gomes, Paula and Araújo, Maria and Söderman, Olle}},
issn = {{0743-7463}},
language = {{eng}},
number = {{19}},
pages = {{11009--11017}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Langmuir}},
title = {{Spontaneous Vesicle Formation in Catanionic Mixtures of Amino Acid-Based Surfactants: Chain Length Symmetry Effects.}},
url = {{http://dx.doi.org/10.1021/la801518h}},
doi = {{10.1021/la801518h}},
volume = {{24}},
year = {{2008}},
}