Interaction between Bile Salt Sodium Glycodeoxycholate and PEO-PPO-PEO Triblock Copolymers in Aqueous Solution
(2016) In RSC Advances 6. p.69313-69325- Abstract
- The interactions of the anionic bile salt NaGDC with three triblock copolymers based on poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), denoted P65, P123 and F127, were investigated using high-sensitive differential scanning calorimetry (DSC), turbidimetry, dynamic and static light scattering and small angle X-ray scattering (SAXS). P65 and P123 had the same hydrophilic PEO block lengths, whereas F127 and P123 had the same hydrophobic PPO block length. In water, the block copolymers self-assembled and formed spherical micelles at a critical micelle temperature, which depended on both the PPO/PEO composition ratio and the molecular weight of the copolymer. The mixed systems were studied at a constant P65, P123 or F127... (More)
- The interactions of the anionic bile salt NaGDC with three triblock copolymers based on poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), denoted P65, P123 and F127, were investigated using high-sensitive differential scanning calorimetry (DSC), turbidimetry, dynamic and static light scattering and small angle X-ray scattering (SAXS). P65 and P123 had the same hydrophilic PEO block lengths, whereas F127 and P123 had the same hydrophobic PPO block length. In water, the block copolymers self-assembled and formed spherical micelles at a critical micelle temperature, which depended on both the PPO/PEO composition ratio and the molecular weight of the copolymer. The mixed systems were studied at a constant P65, P123 or F127 concentration (i.e., 1.0 wt% or 5.0 wt%) with varying nNaGDC/npolymer molar ratio (MR) from 0 to 12. The DSC measurements presented endothermic enthalpy values (correlated to the amount of PPO that dehydrates in the aggregation process) that were suppressed at high MR. At 50 °C, the NaGDC molecules associated to the PPO core – PEO corona interface of the copolymer micelle forming a negatively charged block copolymer micelle–NaGDC complex. The complexes began to disintegrate upon NaGDC addition. Their resistance to disruption followed the stability order as inferred from the CMT values. At 20 °C, the unassociated block copolymer chains interacted with the NaGDC micelles and formed small NaGDC-rich complexes with a radius of ∼2 nm as determined by SAXS. (Less)
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https://lup.lub.lu.se/record/ce6a5ceb-43ff-4cac-9783-529528980fce
- author
- Schillén, Karin LU ; BAYATI, SOLMAZ LU ; Anderberg Haglund, Caroline LU ; Pavel, Nicolae Viorel and Galantini, Luciano
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- RSC Advances
- volume
- 6
- pages
- 13 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:84979916878
- wos:000381512600087
- ISSN
- 2046-2069
- DOI
- 10.1039/C6RA12514J
- language
- English
- LU publication?
- yes
- id
- ce6a5ceb-43ff-4cac-9783-529528980fce
- date added to LUP
- 2016-11-12 11:35:09
- date last changed
- 2022-04-01 03:41:49
@article{ce6a5ceb-43ff-4cac-9783-529528980fce, abstract = {{The interactions of the anionic bile salt NaGDC with three triblock copolymers based on poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), denoted P65, P123 and F127, were investigated using high-sensitive differential scanning calorimetry (DSC), turbidimetry, dynamic and static light scattering and small angle X-ray scattering (SAXS). P65 and P123 had the same hydrophilic PEO block lengths, whereas F127 and P123 had the same hydrophobic PPO block length. In water, the block copolymers self-assembled and formed spherical micelles at a critical micelle temperature, which depended on both the PPO/PEO composition ratio and the molecular weight of the copolymer. The mixed systems were studied at a constant P65, P123 or F127 concentration (i.e., 1.0 wt% or 5.0 wt%) with varying nNaGDC/npolymer molar ratio (MR) from 0 to 12. The DSC measurements presented endothermic enthalpy values (correlated to the amount of PPO that dehydrates in the aggregation process) that were suppressed at high MR. At 50 °C, the NaGDC molecules associated to the PPO core – PEO corona interface of the copolymer micelle forming a negatively charged block copolymer micelle–NaGDC complex. The complexes began to disintegrate upon NaGDC addition. Their resistance to disruption followed the stability order as inferred from the CMT values. At 20 °C, the unassociated block copolymer chains interacted with the NaGDC micelles and formed small NaGDC-rich complexes with a radius of ∼2 nm as determined by SAXS.}}, author = {{Schillén, Karin and BAYATI, SOLMAZ and Anderberg Haglund, Caroline and Pavel, Nicolae Viorel and Galantini, Luciano}}, issn = {{2046-2069}}, language = {{eng}}, pages = {{69313--69325}}, publisher = {{Royal Society of Chemistry}}, series = {{RSC Advances}}, title = {{Interaction between Bile Salt Sodium Glycodeoxycholate and PEO-PPO-PEO Triblock Copolymers in Aqueous Solution}}, url = {{http://dx.doi.org/10.1039/C6RA12514J}}, doi = {{10.1039/C6RA12514J}}, volume = {{6}}, year = {{2016}}, }