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IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes.

Dereke, Jonatan LU ; Nilsson, Charlotta LU ; Strevens, Helena LU ; Landin-Olsson, Mona LU and Hillman, Magnus LU (2016) In Clinical Immunology1999-01-01+01:00 162. p.45-48
Abstract
Some women with gestational diabetes (GDM) present with autoantibodies associated with type 1 diabetes. These are usually directed against glutamic acid decarboxylase (GADA) and suggested to predict development of type 1 diabetes. The primary aim of this study was to investigate if GADA IgG subclasses at onset of GDM could assist in predicting postpartum development. Of 1225 women diagnosed with first-time GDM only 51 were GADA-positive. Total GADA was determined using ELISA. GADA subclasses were determined with radioimmunoassay. Approximately 25% of GADA-positive women developed type 1 diabetes postpartum. Titers of total GADA were higher in women that developed type 1 diabetes (142.1 vs 74.2u/mL; p=0.04) and they also had lower titers of... (More)
Some women with gestational diabetes (GDM) present with autoantibodies associated with type 1 diabetes. These are usually directed against glutamic acid decarboxylase (GADA) and suggested to predict development of type 1 diabetes. The primary aim of this study was to investigate if GADA IgG subclasses at onset of GDM could assist in predicting postpartum development. Of 1225 women diagnosed with first-time GDM only 51 were GADA-positive. Total GADA was determined using ELISA. GADA subclasses were determined with radioimmunoassay. Approximately 25% of GADA-positive women developed type 1 diabetes postpartum. Titers of total GADA were higher in women that developed type 1 diabetes (142.1 vs 74.2u/mL; p=0.04) and they also had lower titers of GADA IgG4 (index=0.01 vs 0.04; p=0.03). In conclusion we found that that women with high titers of total GADA but low titers of GADA IgG4 were more prone to develop type 1 diabetes postpartum. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Immunology1999-01-01+01:00
volume
162
pages
45 - 48
publisher
Elsevier
external identifiers
  • pmid:26548838
  • wos:000368970000006
  • scopus:84946811180
ISSN
1521-6616
DOI
10.1016/j.clim.2015.11.001
language
English
LU publication?
yes
id
ce9b13ef-bf0d-4a03-8269-d106243e7bcb (old id 8240019)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26548838?dopt=Abstract
date added to LUP
2015-12-03 15:36:02
date last changed
2017-03-05 03:04:25
@article{ce9b13ef-bf0d-4a03-8269-d106243e7bcb,
  abstract     = {Some women with gestational diabetes (GDM) present with autoantibodies associated with type 1 diabetes. These are usually directed against glutamic acid decarboxylase (GADA) and suggested to predict development of type 1 diabetes. The primary aim of this study was to investigate if GADA IgG subclasses at onset of GDM could assist in predicting postpartum development. Of 1225 women diagnosed with first-time GDM only 51 were GADA-positive. Total GADA was determined using ELISA. GADA subclasses were determined with radioimmunoassay. Approximately 25% of GADA-positive women developed type 1 diabetes postpartum. Titers of total GADA were higher in women that developed type 1 diabetes (142.1 vs 74.2u/mL; p=0.04) and they also had lower titers of GADA IgG4 (index=0.01 vs 0.04; p=0.03). In conclusion we found that that women with high titers of total GADA but low titers of GADA IgG4 were more prone to develop type 1 diabetes postpartum.},
  author       = {Dereke, Jonatan and Nilsson, Charlotta and Strevens, Helena and Landin-Olsson, Mona and Hillman, Magnus},
  issn         = {1521-6616},
  language     = {eng},
  pages        = {45--48},
  publisher    = {Elsevier},
  series       = {Clinical Immunology1999-01-01+01:00},
  title        = {IgG4 subclass glutamic acid decarboxylase antibodies (GADA) are associated with a reduced risk of developing type 1 diabetes as well as increased C-peptide levels in GADA positive gestational diabetes.},
  url          = {http://dx.doi.org/10.1016/j.clim.2015.11.001},
  volume       = {162},
  year         = {2016},
}