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Enhanced Optical Biosensing by Aerotaxy Ga(As)P Nanowire Platforms Suitable for Scalable Production

Valderas Gutiérrez, Julia LU orcid ; Davtyan, Rubina LU ; Sivakumar, Sudhakar LU ; Anttu, Nicklas ; Li, Yuyu ; Flatt, Patrick ; Shin, Jae Yen ; Prinz, Christelle LU ; Höök, Fredrik and Fioretos, Thoas LU , et al. (2022) In ACS Applied Nano Materials
Abstract
Sensitive detection of low-abundance biomolecules is central for diagnostic applications. Semiconductor nanowires can be designed to enhance the fluorescence signal from surface-bound molecules, prospectively improving the limit of optical detection. However, to achieve the desired control of physical dimensions and material properties, one currently uses relatively expensive substrates and slow epitaxy techniques. An alternative approach is aerotaxy, a high-throughput and substrate-free production technique for high-quality semiconductor nanowires. Here, we compare the optical sensing performance of custom-grown aerotaxy-produced Ga(As)P nanowires vertically aligned on a polymer substrate to GaP nanowires batch-produced by epitaxy on GaP... (More)
Sensitive detection of low-abundance biomolecules is central for diagnostic applications. Semiconductor nanowires can be designed to enhance the fluorescence signal from surface-bound molecules, prospectively improving the limit of optical detection. However, to achieve the desired control of physical dimensions and material properties, one currently uses relatively expensive substrates and slow epitaxy techniques. An alternative approach is aerotaxy, a high-throughput and substrate-free production technique for high-quality semiconductor nanowires. Here, we compare the optical sensing performance of custom-grown aerotaxy-produced Ga(As)P nanowires vertically aligned on a polymer substrate to GaP nanowires batch-produced by epitaxy on GaP substrates. We find that signal enhancement by individual aerotaxy nanowires is comparable to that from epitaxy nanowires and present evidence of single-molecule detection. Platforms based on both types of nanowires show substantially higher normalized-to-blank signal intensity than planar glass surfaces, with the epitaxy platforms performing somewhat better, owing to a higher density of nanowires. With further optimization, aerotaxy nanowires thus offer a pathway to scalable, low-cost production of highly sensitive nanowire-based platforms for optical biosensing applications. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
semiconductor nanowires, aerotaxy, scalable production, biosensing, lightguiding
in
ACS Applied Nano Materials
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:35909504
  • scopus:85134802773
ISSN
2574-0970
DOI
10.1021/acsanm.2c01372
language
English
LU publication?
yes
id
cea238ea-64fb-4302-8cc5-0592806d9bf0
date added to LUP
2022-07-06 17:59:23
date last changed
2023-11-21 10:04:47
@article{cea238ea-64fb-4302-8cc5-0592806d9bf0,
  abstract     = {{Sensitive detection of low-abundance biomolecules is central for diagnostic applications. Semiconductor nanowires can be designed to enhance the fluorescence signal from surface-bound molecules, prospectively improving the limit of optical detection. However, to achieve the desired control of physical dimensions and material properties, one currently uses relatively expensive substrates and slow epitaxy techniques. An alternative approach is aerotaxy, a high-throughput and substrate-free production technique for high-quality semiconductor nanowires. Here, we compare the optical sensing performance of custom-grown aerotaxy-produced Ga(As)P nanowires vertically aligned on a polymer substrate to GaP nanowires batch-produced by epitaxy on GaP substrates. We find that signal enhancement by individual aerotaxy nanowires is comparable to that from epitaxy nanowires and present evidence of single-molecule detection. Platforms based on both types of nanowires show substantially higher normalized-to-blank signal intensity than planar glass surfaces, with the epitaxy platforms performing somewhat better, owing to a higher density of nanowires. With further optimization, aerotaxy nanowires thus offer a pathway to scalable, low-cost production of highly sensitive nanowire-based platforms for optical biosensing applications.}},
  author       = {{Valderas Gutiérrez, Julia and Davtyan, Rubina and Sivakumar, Sudhakar and Anttu, Nicklas and Li, Yuyu and Flatt, Patrick and Shin, Jae Yen and Prinz, Christelle and Höök, Fredrik and Fioretos, Thoas and Magnusson, Martin H. and Linke, Heiner}},
  issn         = {{2574-0970}},
  keywords     = {{semiconductor nanowires; aerotaxy; scalable production; biosensing; lightguiding}},
  language     = {{eng}},
  month        = {{07}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Applied Nano Materials}},
  title        = {{Enhanced Optical Biosensing by Aerotaxy Ga(As)P Nanowire Platforms Suitable for Scalable Production}},
  url          = {{http://dx.doi.org/10.1021/acsanm.2c01372}},
  doi          = {{10.1021/acsanm.2c01372}},
  year         = {{2022}},
}