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The future of stem cell therapies for Parkinson disease

Parmar, Malin LU orcid ; Grealish, Shane LU and Henchcliffe, Claire (2020) In Nature Reviews Neuroscience 21. p.103-115
Abstract
Cell-replacement therapies have long been an attractive prospect for treating Parkinson disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with Parkinson disease have been variable, in part owing to the limitations of fetal tissue as a cell source, relating to its availability and the lack of possibility for standardization and to variation in methods. Advances in developmental and stem cell biology have allowed the development of cell-replacement therapies that comprise dopamine neurons derived from human pluripotent stem cells, which have several advantages over fetal cell-derived therapies. In this Review, we critically assess the potential trajectory of this line of translational and clinical... (More)
Cell-replacement therapies have long been an attractive prospect for treating Parkinson disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with Parkinson disease have been variable, in part owing to the limitations of fetal tissue as a cell source, relating to its availability and the lack of possibility for standardization and to variation in methods. Advances in developmental and stem cell biology have allowed the development of cell-replacement therapies that comprise dopamine neurons derived from human pluripotent stem cells, which have several advantages over fetal cell-derived therapies. In this Review, we critically assess the potential trajectory of this line of translational and clinical research and address its possibilities and current limitations and the broader range of Parkinson disease features that dopamine cell replacement based on generating neurons from human pluripotent stem cells could effectively treat in the future. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neuroscience
volume
21
pages
13 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:31907406
  • scopus:85077322079
ISSN
1471-003X
DOI
10.1038/s41583-019-0257-7
language
English
LU publication?
yes
id
cec2308f-6f16-46bb-a3a4-0bc44e785d04
date added to LUP
2020-03-05 11:46:48
date last changed
2022-05-12 00:56:22
@article{cec2308f-6f16-46bb-a3a4-0bc44e785d04,
  abstract     = {{Cell-replacement therapies have long been an attractive prospect for treating Parkinson disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with Parkinson disease have been variable, in part owing to the limitations of fetal tissue as a cell source, relating to its availability and the lack of possibility for standardization and to variation in methods. Advances in developmental and stem cell biology have allowed the development of cell-replacement therapies that comprise dopamine neurons derived from human pluripotent stem cells, which have several advantages over fetal cell-derived therapies. In this Review, we critically assess the potential trajectory of this line of translational and clinical research and address its possibilities and current limitations and the broader range of Parkinson disease features that dopamine cell replacement based on generating neurons from human pluripotent stem cells could effectively treat in the future.}},
  author       = {{Parmar, Malin and Grealish, Shane and Henchcliffe, Claire}},
  issn         = {{1471-003X}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{103--115}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews Neuroscience}},
  title        = {{The future of stem cell therapies for Parkinson disease}},
  url          = {{http://dx.doi.org/10.1038/s41583-019-0257-7}},
  doi          = {{10.1038/s41583-019-0257-7}},
  volume       = {{21}},
  year         = {{2020}},
}