Pregnancy-induced Cardiovascular Pathologies : Importance of Structural Components and Lipids
(2020) In American Journal of the Medical Sciences 360(5). p.447-466- Abstract
Pregnancy leads to adaptations for maternal and fetal energy needs. The cardiovascular system bears the brunt of the adaptations as the heart and vessels enable nutrient supply to maternal organs facilitated by the placenta to the fetus. The components of the cardiovascular system are critical in the balance between maternal homeostatic and fetus driven homeorhetic regulation. Since lipids intersect maternal cardiovascular function and fetal needs with growth and in stress, factors affecting lipid deposition and mobilization impact risk outcomes. Here, the cardiovascular components and functional derangements associated with cardiovascular pathology in pregnancy, vis-à-vis lipid deposition, mobilization and maternal and/or cardiac and... (More)
Pregnancy leads to adaptations for maternal and fetal energy needs. The cardiovascular system bears the brunt of the adaptations as the heart and vessels enable nutrient supply to maternal organs facilitated by the placenta to the fetus. The components of the cardiovascular system are critical in the balance between maternal homeostatic and fetus driven homeorhetic regulation. Since lipids intersect maternal cardiovascular function and fetal needs with growth and in stress, factors affecting lipid deposition and mobilization impact risk outcomes. Here, the cardiovascular components and functional derangements associated with cardiovascular pathology in pregnancy, vis-à-vis lipid deposition, mobilization and maternal and/or cardiac and fetal energy needs are detailed. Most reports on the components and associated pathology in pregnancy, are on derangements affecting the extracellular matrix and epicardial fat, followed by the endothelium, vascular smooth muscle, pericytes and myocytes. Targeted studies on all cardiovascular components and pathological outcomes in pregnancy will enhance targeted interventions.
(Less)
- author
- Aleksenko, Larysa LU and Quaye, Isaac K.
- organization
- publishing date
- 2020-11-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiovascular components, Cardiovascular pathology, Lipids, Pregnancy
- in
- American Journal of the Medical Sciences
- volume
- 360
- issue
- 5
- pages
- 20 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85086513251
- pmid:32540145
- ISSN
- 0002-9629
- DOI
- 10.1016/j.amjms.2020.05.014
- language
- English
- LU publication?
- yes
- id
- cec9b7dc-be43-49ad-bc4e-4cfbece7a715
- date added to LUP
- 2020-07-06 14:48:30
- date last changed
- 2024-03-20 12:42:49
@article{cec9b7dc-be43-49ad-bc4e-4cfbece7a715,
abstract = {{<p>Pregnancy leads to adaptations for maternal and fetal energy needs. The cardiovascular system bears the brunt of the adaptations as the heart and vessels enable nutrient supply to maternal organs facilitated by the placenta to the fetus. The components of the cardiovascular system are critical in the balance between maternal homeostatic and fetus driven homeorhetic regulation. Since lipids intersect maternal cardiovascular function and fetal needs with growth and in stress, factors affecting lipid deposition and mobilization impact risk outcomes. Here, the cardiovascular components and functional derangements associated with cardiovascular pathology in pregnancy, vis-à-vis lipid deposition, mobilization and maternal and/or cardiac and fetal energy needs are detailed. Most reports on the components and associated pathology in pregnancy, are on derangements affecting the extracellular matrix and epicardial fat, followed by the endothelium, vascular smooth muscle, pericytes and myocytes. Targeted studies on all cardiovascular components and pathological outcomes in pregnancy will enhance targeted interventions.</p>}},
author = {{Aleksenko, Larysa and Quaye, Isaac K.}},
issn = {{0002-9629}},
keywords = {{Cardiovascular components; Cardiovascular pathology; Lipids; Pregnancy}},
language = {{eng}},
month = {{11}},
number = {{5}},
pages = {{447--466}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{American Journal of the Medical Sciences}},
title = {{Pregnancy-induced Cardiovascular Pathologies : Importance of Structural Components and Lipids}},
url = {{http://dx.doi.org/10.1016/j.amjms.2020.05.014}},
doi = {{10.1016/j.amjms.2020.05.014}},
volume = {{360}},
year = {{2020}},
}